Amphiphilic tetracationic porphyrins are exceptionally active antimicrobial photosensitizers: In vitro and in vivo studies with the free-base and Pd-chelate.
Animals
Anti-Infective Agents
/ chemistry
Candida albicans
/ drug effects
Chelating Agents
/ chemistry
Escherichia coli
/ drug effects
Female
Hydrophobic and Hydrophilic Interactions
Mice
Palladium
/ chemistry
Photosensitizing Agents
/ chemistry
Porphyrins
/ chemistry
Singlet Oxygen
/ metabolism
Superoxides
/ metabolism
amphiphilic tetracationic porphyrins
antimicrobial photodynamic inactivation
bioluminescence imaging
broad-spectrum activity
palladium-porphyrin
uropathogenic Escherichia coli infection
Journal
Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
21
08
2018
revised:
20
01
2019
accepted:
20
01
2019
pubmed:
23
1
2019
medline:
15
9
2020
entrez:
23
1
2019
Statut:
ppublish
Résumé
Antimicrobial photodynamic inactivation (aPDI) employs the combination of nontoxic photosensitizing dyes and visible light to kill pathogenic microorganisms regardless of drug-resistance, and can be used to treat localized infections. A meso-substituted tetra-methylpyridinium porphyrin with one methyl group replaced by a C12 alkyl chain (FS111) and its Pd-derivative (FS111-Pd) were synthesized and tested as broad-spectrum antimicrobial photosensitizers when excited by blue light (5 or 10 J/cm
Identifiants
pubmed: 30667177
doi: 10.1002/jbio.201800318
pmc: PMC6646111
mid: NIHMS1008934
doi:
Substances chimiques
Anti-Infective Agents
0
Chelating Agents
0
Photosensitizing Agents
0
Porphyrins
0
Superoxides
11062-77-4
Singlet Oxygen
17778-80-2
Palladium
5TWQ1V240M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e201800318Subventions
Organisme : Poland National Science Center
ID : 2011/03/B/NZ1/00007
Pays : International
Organisme : Guangxi Scientific and Technological Project
ID : 1355005-1-2
Pays : International
Organisme : NIAID NIH HHS
ID : R21 AI121700
Pays : United States
Organisme : National Natural Science Foundation of China
ID : 81373700
Pays : International
Organisme : Guangxi Natural Science Foundation
ID : 2014GXNSFAA118162
Pays : International
Organisme : Poland National Science Center
ID : 2013/08/W/NZ3/00700
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81860369
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81774374
Pays : International
Organisme : Fulbright Foundation
Pays : International
Organisme : Guangxi Natural Science Foundation
ID : 2016GXNSFAA380312
Pays : International
Organisme : NIH HHS
ID : R01AI050875
Pays : United States
Organisme : National Natural Science Foundation of China
ID : 81260239
Pays : International
Organisme : NIH HHS
ID : R21AI121700
Pays : United States
Organisme : National Natural Science Foundation of China
ID : 81472002
Pays : International
Organisme : NIAID NIH HHS
ID : R01 AI050875
Pays : United States
Organisme : National Natural Science Foundation of China
ID : 81260552
Pays : International
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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