DNA methylation GrimAge strongly predicts lifespan and healthspan.

Adipose Tissue / diagnostic imaging Aging Biomarkers / blood Blood Proteins DNA Methylation Databases, Factual Diet Dietary Supplements Education Fatty Acids, Omega-3 / administration & dosage Female Humans Life Style Longevity Longitudinal Studies Male Predictive Value of Tests Reproducibility of Results Tomography, X-Ray Computed
DNA methylation epigenetics mortality proteomics

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
21 01 2019
Historique:
received: 24 08 2018
accepted: 22 11 1969
pubmed: 23 1 2019
medline: 4 4 2020
entrez: 23 1 2019
Statut: ppublish

Résumé

It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful predictor of lifespan. We present here, seven DNAm-based estimators of plasma proteins including those of plasminogen activator inhibitor 1 (PAI-1) and growth differentiation factor 15. The resulting predictor of lifespan, DNAm GrimAge (in units of years), is a composite biomarker based on the seven DNAm surrogates and a DNAm-based estimator of smoking pack-years. Adjusting DNAm GrimAge for chronological age generated novel measure of epigenetic age acceleration,

Identifiants

DOI: 10.18632/aging.101684 PMID: 30669119 PMC: PMC6366976
pubmed: 30669119
pii: 101684
doi: 10.18632/aging.101684
pmc: PMC6366976
doi:

Substances chimiques

Biomarkers 0
Blood Proteins 0
Fatty Acids, Omega-3 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

303-327

Subventions

Organisme : NHLBI NIH HHS
ID : HHSN268201300048C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201300049C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC25195
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201300046C
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115428
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG060908
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600002C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL116446
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES020836
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600018C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600003C
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG029451
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201300047C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201300050C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201600004C
Pays : United States

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Auteurs

Ake T Lu (AT)

Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

Austin Quach (A)

Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

James G Wilson (JG)

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.

Alex P Reiner (AP)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Abraham Aviv (A)

Center of Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, NJ 07103, USA.

Kenneth Raj (K)

Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 0RQ, United Kingdom.

Lifang Hou (L)

Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Andrea A Baccarelli (AA)

Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.

Yun Li (Y)

Departments of Genetics, Biostatistics, Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA.

James D Stewart (JD)

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.

Eric A Whitsel (EA)

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27516, USA.

Themistocles L Assimes (TL)

Department of Medicine (Division of Cardiovascular Medicine), Stanford University School of Medicine, Stanford, CA 94305, USA.
VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.

Luigi Ferrucci (L)

Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, USA, Baltimore, MD 21224, USA.

Steve Horvath (S)

Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA.

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questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › DNA methylation GrimAge strongly predicts...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › DNA methylation GrimAge strongly predicts...
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