Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors.
Animals
Cells, Cultured
Ceramides
/ chemistry
Enzyme Inhibitors
/ chemistry
Fibroblasts
/ drug effects
Glucosylceramidase
/ antagonists & inhibitors
Humans
Hydrolysis
Imino Pyranoses
/ chemistry
Imino Sugars
/ chemistry
Isomerism
Lysosomes
Melanoma, Experimental
Mice
Molecular Docking Simulation
Molecular Structure
Piperidines
/ chemistry
Protein Binding
Pyrrolidines
/ chemistry
Structure-Activity Relationship
Gaucher disease
glucocerebrosidase
glucosylceramide synthase inhibitors
glycosidase inhibitors
iminosugars
ligand docking
pharmacological chaperones
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
19 Jan 2019
19 Jan 2019
Historique:
received:
18
12
2018
revised:
10
01
2019
accepted:
12
01
2019
entrez:
24
1
2019
pubmed:
24
1
2019
medline:
15
10
2019
Statut:
epublish
Résumé
A series of simple
Identifiants
pubmed: 30669468
pii: molecules24020354
doi: 10.3390/molecules24020354
pmc: PMC6359432
pii:
doi:
Substances chimiques
Ceramides
0
Enzyme Inhibitors
0
Imino Pyranoses
0
Imino Sugars
0
Piperidines
0
Pyrrolidines
0
isofagomine
0
piperidine
67I85E138Y
Glucosylceramidase
EC 3.2.1.45
pyrrolidine
LJU5627FYV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Vaincre les Maladies Lysosomales
ID : Design of new polypharmacophoric dendrimers for an innovative dual therapeutic strategy for Gaucher disease
Organisme : Agence Nationale de la Recherche
ID : ShingoDR
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