The Oncogene Addiction Switch from NOTCH to PI3K Requires Simultaneous Targeting of NOTCH and PI3K Pathway Inhibition in Glioblastoma.
NOTCH
PI3K pathway
PTEN
glioblastoma
glioma initiating cell
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
20 Jan 2019
20 Jan 2019
Historique:
received:
16
12
2018
revised:
11
01
2019
accepted:
19
01
2019
entrez:
24
1
2019
pubmed:
24
1
2019
medline:
24
1
2019
Statut:
epublish
Résumé
The NOTCH pathway regulates neural stem cells and glioma initiating cells (GICs). However, blocking NOTCH activity with γ-secretase inhibitors (GSIs) fails to alter the growth of GICs, as GSIs seem to be active in only a fraction of GICs lines with constitutive NOTCH activity. Here we report loss of
Identifiants
pubmed: 30669546
pii: cancers11010121
doi: 10.3390/cancers11010121
pmc: PMC6356490
pii:
doi:
Types de publication
Journal Article
Langues
eng
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