Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018.
Amino Acid Substitution
/ genetics
Antiviral Agents
/ administration & dosage
Dibenzothiepins
Drug Resistance, Viral
/ drug effects
Endonucleases
/ antagonists & inhibitors
Humans
Influenza A Virus, H3N2 Subtype
/ drug effects
Influenza, Human
/ diagnosis
Japan
Microbial Sensitivity Tests
Morpholines
Oxazines
/ therapeutic use
Pyridines
/ therapeutic use
Pyridones
Thiepins
/ therapeutic use
Treatment Outcome
Triazines
/ therapeutic use
Influenza virus
baloxavir acid
baloxavir marboxil
cap-dependent endonuclease inhibitor
resistant
Journal
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
ISSN: 1560-7917
Titre abrégé: Euro Surveill
Pays: Sweden
ID NLM: 100887452
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
entrez:
24
1
2019
pubmed:
24
1
2019
medline:
10
7
2020
Statut:
ppublish
Résumé
The novel cap-dependent endonuclease inhibitor baloxavir marboxil was approved for the treatment of influenza virus infection in Japan in February 2018. Two influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic subunit (PA) were detected in baloxavir-treated children in December 2018. This mutation is known to confer reduced susceptibility to baloxavir, and the two mutant viruses exhibited 76- and 120-fold reduced susceptibility to baloxavir.
Identifiants
pubmed: 30670142
doi: 10.2807/1560-7917.ES.2019.24.3.1800698
pmc: PMC6344841
doi:
Substances chimiques
Antiviral Agents
0
Dibenzothiepins
0
Morpholines
0
Oxazines
0
Pyridines
0
Pyridones
0
Thiepins
0
Triazines
0
baloxavir
4G86Y4JT3F
Endonucleases
EC 3.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Antivir Ther. 2007;12(4 Pt B):603-16
pubmed: 17944268
Wkly Epidemiol Rec. 2012 Sep 28;87(39):369-74
pubmed: 23061103
Influenza Other Respir Viruses. 2017 May;11(3):240-246
pubmed: 28146320
Sci Rep. 2018 Jun 25;8(1):9633
pubmed: 29941893
N Engl J Med. 2018 Sep 6;379(10):913-923
pubmed: 30184455
Front Microbiol. 2018 Dec 06;9:3026
pubmed: 30574137