LncRNA MEG8 regulates vascular smooth muscle cell proliferation, migration and apoptosis by targeting PPARα.
MEG8
Migration
PPARα
Proliferation
Vascular smooth muscle cells
miR-181a-5p
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
26 02 2019
26 02 2019
Historique:
received:
06
01
2019
accepted:
16
01
2019
pubmed:
24
1
2019
medline:
30
11
2019
entrez:
24
1
2019
Statut:
ppublish
Résumé
Atherosclerosis is the leading risk factor for cardiovascular disease, in which vascular smooth muscle cell (VSMC) proliferation and apoptosis play an important role. Research has demonstrated that long non-coding RNAs (lncRNAs) are critical regulatory factors for VSMC function, however, the molecular mechanism leading to this pathology is still not fully understood. To explore this further, an ox-LDL induced VSMC model was established, in which lncRNA MEG8 expression was suppressed, while miR-181a-5p was enhanced in a dose- and time-dependent manner. Enhanced MEG8 expression suppressed the proliferation and migration ability of VSMCs, and induced apoptosis. Mechanically, MEG8 was found to promote the PPARα protein via sponging miR-181a-5p. Rescue experiments demonstrated that MEG8 and PPARα collectively regulate the proliferation, migration and apoptosis of VSMCs. Overall, this research illustrates that MEG8 regulates the proliferation and migration of VSMCs via the MEG8/miR-181a/PPARα axis.
Identifiants
pubmed: 30670309
pii: S0006-291X(19)30088-9
doi: 10.1016/j.bbrc.2019.01.074
pii:
doi:
Substances chimiques
Lipoproteins, LDL
0
MIrn181 microRNA, human
0
MicroRNAs
0
PPAR alpha
0
RNA, Long Noncoding
0
oxidized low density lipoprotein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
171-176Informations de copyright
Copyright © 2019. Published by Elsevier Inc.