Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study.
antifungal agents
antifungal therapy
mathematical modeling
pharmacokinetics
population pharmacokinetics
software
voriconazole
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
04
11
2018
accepted:
17
01
2019
pubmed:
24
1
2019
medline:
27
2
2020
entrez:
24
1
2019
Statut:
epublish
Résumé
Voriconazole is a first-line antifungal agent. Therapeutic drug monitoring is a standard of care. The best way to adjust dosages to achieve desired drug exposure endpoints is unclear due to nonlinear and variable pharmacokinetics. Previously described software was used to prospectively adjust voriconazole dosages. The
Identifiants
pubmed: 30670416
pii: AAC.02353-18
doi: 10.1128/AAC.02353-18
pmc: PMC6496160
pii:
doi:
Substances chimiques
Antifungal Agents
0
Cytochrome P-450 Enzyme System
9035-51-2
Voriconazole
JFU09I87TR
Banques de données
EudraCT
['2013-0025878-34']
ISRCTN
['ISRCTN83902726']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Department of Health
ID : CS/08/08/10
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L006758/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Hope et al.
Références
Antimicrob Agents Chemother. 2015;59(6):3090-7
pubmed: 25779580
Ther Drug Monit. 2012 Aug;34(4):467-76
pubmed: 22722776
Clin Infect Dis. 2016 Aug 15;63(4):e1-e60
pubmed: 27365388
Clin Microbiol Infect. 2014 Apr;20 Suppl 3:27-46
pubmed: 24548001
Antimicrob Agents Chemother. 2013 Apr;57(4):1888-94
pubmed: 23380734
Antimicrob Agents Chemother. 2011 Oct;55(10):4782-8
pubmed: 21768513
Antimicrob Agents Chemother. 2012 Jan;56(1):526-31
pubmed: 22064545
Lancet Infect Dis. 2014 Jun;14(6):498-509
pubmed: 24768475
J Antimicrob Chemother. 2014 May;69(5):1162-76
pubmed: 24379304
Clin Infect Dis. 2012 Oct;55(8):1080-7
pubmed: 22761409
Clin Infect Dis. 2010 Jan 1;50(1):27-36
pubmed: 19951112
Clin Infect Dis. 2008 Jan 15;46(2):201-11
pubmed: 18171251