Characterization of the housekeeping sortase from the human pathogen

Aminoacyltransferases / chemistry Bacterial Proteins / chemistry Cysteine Endopeptidases / chemistry Genome, Bacterial Humans Hydrogen-Ion Concentration Propionibacterium acnes / enzymology Staphylococcus aureus / enzymology
Gram-positive bacteria antibody–drug conjugation enzyme activity sorting transpeptidation

Journal

The Biochemical journal
ISSN: 1470-8728
Titre abrégé: Biochem J
Pays: England
ID NLM: 2984726R

Informations de publication

Date de publication:
19 02 2019
Historique:
received: 15 11 2018
revised: 15 01 2019
accepted: 18 01 2019
pubmed: 24 1 2019
medline: 19 12 2019
entrez: 24 1 2019
Statut: epublish

Résumé

Sortase enzymes play an important role in Gram-positive bacteria. They are responsible for the covalent attachment of proteins to the surface of the bacteria and perform this task via a highly sequence-specific transpeptidation reaction. Since these immobilized proteins are often involved in pathogenicity of Gram-positive bacteria, characterization of this type of enzyme is also of medical relevance. Different classes of sortases (A-F) have been found, which recognize characteristic recognition sequences present in substrate proteins. Up to date, sortase A from

Identifiants

DOI: 10.1042/BCJ20180885 PMID: 30670573
pubmed: 30670573
pii: BCJ20180885
doi: 10.1042/BCJ20180885
doi:

Substances chimiques

Bacterial Proteins 0
Aminoacyltransferases EC 2.3.2.-
Cysteine Endopeptidases EC 3.4.22.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

665-682

Informations de copyright

© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Auteurs

Salvatore Di Girolamo (S)

Institute for Chemistry and Bioanalytics, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132 Muttenz, Switzerland.
Department of Chemistry, University of Basel, Spitalstrasse 51, 4056 Basel, Switzerland.

Chasper Puorger (C)

Institute for Chemistry and Bioanalytics, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132 Muttenz, Switzerland.

Mara Castiglione (M)

Institute for Chemistry and Bioanalytics, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132 Muttenz, Switzerland.

Maren Vogel (M)

Institute for Chemistry and Bioanalytics, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132 Muttenz, Switzerland.

Rémy Gébleux (R)

NBE-Therapeutics AG, Hochbergerstrasse 60C, 4057 Basel, Switzerland.

Manfred Briendl (M)

NBE-Therapeutics AG, Hochbergerstrasse 60C, 4057 Basel, Switzerland.

Tamara Hell (T)

NBE-Therapeutics AG, Hochbergerstrasse 60C, 4057 Basel, Switzerland.

Roger R Beerli (RR)

NBE-Therapeutics AG, Hochbergerstrasse 60C, 4057 Basel, Switzerland.

Ulf Grawunder (U)

NBE-Therapeutics AG, Hochbergerstrasse 60C, 4057 Basel, Switzerland.

Georg Lipps (G)

Institute for Chemistry and Bioanalytics, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 30, 4132 Muttenz, Switzerland georg.lipps@fhnw.ch.
ORCID: 0000-0002-5376-9716

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Aminoacyltransferases › Characterization of the housekeeping sortase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Characterization of the housekeeping sortase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Cysteine endopeptidases › Characterization of the housekeeping sortase...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › Characterization of the housekeeping sortase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Characterization of the housekeeping sortase...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Characterization of the housekeeping sortase...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes irréguliers à Gram positif › Propionibacteriaceae › Propionibacterium › Propionibacterium acnes › Characterization of the housekeeping sortase...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Characterization of the housekeeping sortase...