Microbe-focused glycan array screening platform.
antiglycan antibodies
bacterial lectins
glycan arrays
immune receptors
microbial antigens
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
05 02 2019
05 02 2019
Historique:
pubmed:
24
1
2019
medline:
13
4
2019
entrez:
24
1
2019
Statut:
ppublish
Résumé
Interactions between glycans and glycan binding proteins are essential for numerous processes in all kingdoms of life. Glycan microarrays are an excellent tool to examine protein-glycan interactions. Here, we present a microbe-focused glycan microarray platform based on oligosaccharides obtained by chemical synthesis. Glycans were generated by combining different carbohydrate synthesis approaches including automated glycan assembly, solution-phase synthesis, and chemoenzymatic methods. The current library of more than 300 glycans is as diverse as the mammalian glycan array from the Consortium for Functional Glycomics and, due to its microbial focus, highly complementary. This glycan platform is essential for the characterization of various classes of glycan binding proteins. Applications of this glycan array platform are highlighted by the characterization of innate immune receptors and bacterial virulence factors as well as the analysis of human humoral immunity to pathogenic glycans.
Identifiants
pubmed: 30670663
pii: 1800853116
doi: 10.1073/pnas.1800853116
pmc: PMC6369816
doi:
Substances chimiques
Antigens, Bacterial
0
Carrier Proteins
0
Lectins
0
Oligosaccharides
0
Polysaccharides
0
Recombinant Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1958-1967Références
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