Recombinant asialoerythropoetin protects HL-1 cardiomyocytes from injury via suppression of Mst1 activation.
Apoptosis
Asialo-rhuEPO
Autophagy
Cardioprotection
Mst1
Journal
Biochemistry and biophysics reports
ISSN: 2405-5808
Titre abrégé: Biochem Biophys Rep
Pays: Netherlands
ID NLM: 101660999
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
06
12
2018
revised:
02
01
2019
accepted:
04
01
2019
entrez:
24
1
2019
pubmed:
24
1
2019
medline:
24
1
2019
Statut:
epublish
Résumé
Recombinant human erythropoietin (rhuEPO) and asialoerythropoietin (asialo-rhuEPO) are cardioprotective. However, the protective effects of rhuEPO could not be translated into clinical practice because of its hematopoiesis-associated side effects while non-erythropoietic asialo-rhuEPO is unavailable in large quantities for clinical studies. This study was designed to investigate the cardiomyocyte protective potential of plant-produced asialo-rhuEPO (asialo-rhuEPO HL-1 cardiomyocytes were simultaneously treated with STS and asialo-rhuEPO Our results showed that 20 IU/ml asialo-rhuEPO Asialo-rhuEPO Asialo-rhuEPO
Sections du résumé
BACKGROUND
BACKGROUND
Recombinant human erythropoietin (rhuEPO) and asialoerythropoietin (asialo-rhuEPO) are cardioprotective. However, the protective effects of rhuEPO could not be translated into clinical practice because of its hematopoiesis-associated side effects while non-erythropoietic asialo-rhuEPO is unavailable in large quantities for clinical studies. This study was designed to investigate the cardiomyocyte protective potential of plant-produced asialo-rhuEPO (asialo-rhuEPO
METHODS
METHODS
HL-1 cardiomyocytes were simultaneously treated with STS and asialo-rhuEPO
RESULTS
RESULTS
Our results showed that 20 IU/ml asialo-rhuEPO
CONCLUSIONS
CONCLUSIONS
Asialo-rhuEPO
GENERAL SIGNIFICANCE
CONCLUSIONS
Asialo-rhuEPO
Identifiants
pubmed: 30671548
doi: 10.1016/j.bbrep.2019.01.004
pii: S2405-5808(18)30306-6
pmc: PMC6327940
doi:
Types de publication
Journal Article
Langues
eng
Pagination
157-168Subventions
Organisme : NIGMS NIH HHS
ID : SC1 GM111178
Pays : United States
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