Evolution of white matter tract microstructure across the life span.
MRI
aging
degeneration
development
intracellular volume fraction (ICVF)
iron
life span
longitudinal (R1) and transverse (R2*) relaxation rates
mean diffusivity (MD)
myelin
quantitative magnetic resonance imaging (qMRI)
tractography
white matter
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
05
07
2018
revised:
28
12
2018
accepted:
02
01
2019
pubmed:
24
1
2019
medline:
14
4
2020
entrez:
24
1
2019
Statut:
ppublish
Résumé
The human brain undergoes dramatic structural change over the life span. In a large imaging cohort of 801 individuals aged 7-84 years, we applied quantitative relaxometry and diffusion microstructure imaging in combination with diffusion tractography to investigate tissue property dynamics across the human life span. Significant nonlinear aging effects were consistently observed across tracts and tissue measures. The age at which white matter (WM) fascicles attain peak maturation varies substantially across tissue measurements and tracts. These observations of heterochronicity and spatial heterogeneity of tract maturation highlight the importance of using multiple tissue measurements to investigate each region of the WM. Our data further provide additional quantitative evidence in support of the last-in-first-out retrogenesis hypothesis of aging, demonstrating a strong correlational relationship between peak maturational timing and the extent of quadratic measurement differences across the life span for the most myelin sensitive measures. These findings present an important baseline from which to assess divergence from normative aging trends in developmental and degenerative disorders, and to further investigate the mechanisms connecting WM microstructure to cognition.
Identifiants
pubmed: 30673158
doi: 10.1002/hbm.24522
pmc: PMC6865588
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2252-2268Subventions
Organisme : Fondation Leenaards
Pays : International
Organisme : Roger De Spoelberch and Partridge Foundations
Pays : International
Organisme : Swiss National Science Foundation
ID : 32003B_159780
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 33CS30-148401
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 33CS30-139468
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 33CSCO-122661
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 3200B0-118308
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 3200B0-105993
Pays : Switzerland
Organisme : GlaxoSmithKline
Pays : International
Organisme : European Union's Horizon 2020 Research and Innovation Program
ID : 720270
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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