Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.

Animals Cellular Senescence / genetics Hematopoietic Stem Cells / immunology Inflammasomes / immunology Mice Mice, Knockout Mitochondria / genetics NLR Family, Pyrin Domain-Containing 3 Protein / immunology Sirtuin 2 / genetics Stress, Physiological / genetics
NLRP3 SIRT2 SIRT3 SIRT7 aging clonal hematopoiesis hematopoietic stem cell inflammasome mitochondrial UPR oxidative stress

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
22 01 2019
Historique:
received: 13 09 2018
revised: 05 12 2018
accepted: 26 12 2018
entrez: 24 1 2019
pubmed: 24 1 2019
medline: 7 3 2020
Statut: ppublish

Résumé

Aging-associated defects in hematopoietic stem cells (HSCs) can manifest in their progeny, leading to aberrant activation of the NLRP3 inflammasome in macrophages and affecting distant tissues and organismal health span. Whether the NLRP3 inflammasome is aberrantly activated in HSCs during physiological aging is unknown. We show here that SIRT2, a cytosolic NAD

Identifiants

DOI: 10.1016/j.celrep.2018.12.101 PMID: 30673616 PMC: PMC6371804
pubmed: 30673616
pii: S2211-1247(18)32076-X
doi: 10.1016/j.celrep.2018.12.101
pmc: PMC6371804
mid: NIHMS1519387
pii:
doi:

Substances chimiques

Inflammasomes 0
NLR Family, Pyrin Domain-Containing 3 Protein 0
Nlrp3 protein, mouse 0
Sirt2 protein, mouse EC 3.5.1.-
Sirtuin 2 EC 3.5.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

945-954.e4

Subventions

Organisme : NIA NIH HHS
ID : R01 AG063404
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI101935
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117481
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098263
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG000266
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101885
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124346
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115577
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI101935
Pays : United States

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Hanzhi Luo (H)

Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.

Wei-Chieh Mu (WC)

Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.

Rajendra Karki (R)

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Hou-Hsien Chiang (HH)

Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.

Mary Mohrin (M)

Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.

Jiyung J Shin (JJ)

Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.

Rika Ohkubo (R)

Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.

Keisuke Ito (K)

Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Departments of Cell Biology and Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Thirumala-Devi Kanneganti (TD)

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Danica Chen (D)

Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA. Electronic address: danicac@berkeley.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mitochondrial Stress-Initiated Aberrant...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Mitochondrial Stress-Initiated Aberrant...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Mitochondrial Stress-Initiated Aberrant...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Mitochondrial Stress-Initiated Aberrant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mitochondrial Stress-Initiated Aberrant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Mitochondrial Stress-Initiated Aberrant...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondrial Stress-Initiated Aberrant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › Mitochondrial Stress-Initiated Aberrant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Sirtuines › Sirtuine-2 › Mitochondrial Stress-Initiated Aberrant...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Mitochondrial Stress-Initiated Aberrant...