Epithelial stratification shapes infection dynamics.
Journal
PLoS computational biology
ISSN: 1553-7358
Titre abrégé: PLoS Comput Biol
Pays: United States
ID NLM: 101238922
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
30
01
2018
accepted:
16
11
2018
revised:
04
02
2019
pubmed:
24
1
2019
medline:
5
3
2019
entrez:
24
1
2019
Statut:
epublish
Résumé
Infections of stratified epithelia contribute to a large group of common diseases, such as dermatological conditions and sexually transmitted diseases. To investigate how epithelial structure affects infection dynamics, we develop a general ecology-inspired model for stratified epithelia. Our model allows us to simulate infections, explore new hypotheses and estimate parameters that are difficult to measure with tissue cell cultures. We focus on two contrasting pathogens: Chlamydia trachomatis and Human papillomaviruses (HPV). Using cervicovaginal parameter estimates, we find that key infection symptoms can be explained by differential interactions with the layers, while clearance and pathogen burden appear to be bottom-up processes. Cell protective responses to infections (e.g. mucus trapping) generally lowered pathogen load but there were specific effects based on infection strategies. Our modeling approach opens new perspectives for 3D tissue culture experimental systems of infections and, more generally, for developing and testing hypotheses related to infections of stratified epithelia.
Identifiants
pubmed: 30673699
doi: 10.1371/journal.pcbi.1006646
pii: PCOMPBIOL-D-18-00154
pmc: PMC6361466
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1006646Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Invest Dermatol. 2014 Jun;134(6):1527-1534
pubmed: 24166134
Nat Med. 2008 Mar;14(3):275-81
pubmed: 18264110
Ecol Lett. 2008 Jul;11(7):740-55
pubmed: 18445030
J Theor Biol. 2012 Oct 7;310:105-14
pubmed: 22683365
Nature. 2007 Mar 8;446(7132):185-9
pubmed: 17330052
PLoS One. 2014 Jul 01;9(7):e101540
pubmed: 24983759
Curr Opin Virol. 2016 Oct;20:129-136
pubmed: 27600900
Trends Microbiol. 2016 Sep;24(9):750-765
pubmed: 27320172
J Reprod Immunol. 2011 Mar;88(2):185-94
pubmed: 21353708
PLoS One. 2009 Sep 03;4(9):e6886
pubmed: 19727394
PLoS Pathog. 2014 Aug 07;10(8):e1004111
pubmed: 25101790
Math Biosci. 2003 Mar;182(1):27-44
pubmed: 12547038
Cancer Med. 2015 Aug;4(8):1294-302
pubmed: 25991420
Science. 2012 Aug 31;337(6098):1091-3
pubmed: 22821983
Br J Dermatol. 2009 Sep;161(3):528-35
pubmed: 19519829
Clin Microbiol Infect. 2009 Jan;15(1):4-10
pubmed: 19220334
Sci Transl Med. 2009 Nov 18;1(7):7ra16
pubmed: 20161655
Trends Microbiol. 2005 Jun;13(6):269-77
pubmed: 15936659
Annu Rev Virol. 2015 Nov;2(1):403-23
pubmed: 26958922
Cell. 2009 Jul 10;138(1):30-50
pubmed: 19596234
Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Aug;76(2 Pt 1):021910
pubmed: 17930068
Bull Math Biol. 2017 Jul;79(7):1564-1585
pubmed: 28608043
BMC Genomics. 2017 Mar 14;18(1):231
pubmed: 28288568
Opt Express. 2003 Dec 1;11(24):3171-81
pubmed: 19471442
J Cell Sci. 2017 Jan 15;130(2):307-314
pubmed: 28062847
BMC Biol. 2013 Sep 03;11:96
pubmed: 24020860
Andrology. 2015 Mar;3(2):163-73
pubmed: 25270519
Semin Cancer Biol. 2014 Jun;26:13-21
pubmed: 24316445
Viruses. 2017 Oct 10;9(10):
pubmed: 28994707
PLoS Pathog. 2013;9(10):e1003685
pubmed: 24146621
Theor Popul Biol. 2014 May;93:52-62
pubmed: 24513099
PLoS Comput Biol. 2015 Mar 13;11(3):e1004113
pubmed: 25769112
Microb Cell. 2016 Sep 05;3(9):361-362
pubmed: 28357374
Mucosal Immunol. 2017 Jan;10(1):35-45
pubmed: 27049062
Am J Obstet Gynecol. 1970 Sep 1;108(1):8-17
pubmed: 5454588
J Clin Virol. 2011 May;51(1):44-9
pubmed: 21388867
Nat Rev Microbiol. 2008 Nov;6(11):815-26
pubmed: 18923409
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20458-63
pubmed: 19920181
Curr Opin Infect Dis. 2008 Feb;21(1):49-55
pubmed: 18192786
Physiol Meas. 2003 Feb;24(1):121-35
pubmed: 12636191
Lancet Infect Dis. 2011 Nov;11(11):868-78
pubmed: 22035615
J Invest Dermatol. 2000 Mar;114(3):444-55
pubmed: 10692102
Am Nat. 2008 Nov;172(5):214-38
pubmed: 18834302
J R Soc Interface. 2013 Jul 17;10(86):20121018
pubmed: 23864497
J Theor Biol. 2014 Jun 7;350:98-109
pubmed: 24412334
Virology. 2016 Aug;495:52-62
pubmed: 27179345
Vaccine. 2006 Aug 31;24 Suppl 3:S3/63-70
pubmed: 16950019
Nat Rev Microbiol. 2010 Nov;8(11):791-801
pubmed: 20948552
BMC Genomics. 2016 Nov 2;17(1):851
pubmed: 27806689
Vaccine. 2012 Nov 20;30 Suppl 5:F55-70
pubmed: 23199966
J Infect Dis. 2013 Aug 1;208(3):394-402
pubmed: 23599315
Biol Reprod. 2011 Jul;85(1):97-104
pubmed: 21471299
Trends Ecol Evol. 2011 Sep;26(9):457-66
pubmed: 21680049
Trends Ecol Evol. 1996 Sep;11(9):386-9
pubmed: 21237891
PLoS Pathog. 2015 Dec 03;11(12):e1005229
pubmed: 26632822
Nat Rev Mol Cell Biol. 2009 Mar;10(3):207-17
pubmed: 19209183
J Clin Microbiol. 2013 May;51(5):1458-64
pubmed: 23447632
PLoS One. 2016 Jun 30;11(6):e0158338
pubmed: 27362256
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16544-9
pubmed: 25313069
Lancet Infect Dis. 2011 Mar;11(3):236-47
pubmed: 21371657
Monogr Popul Biol. 1982;17:1-296
pubmed: 7162524
Am J Obstet Gynecol. 2000 Oct;183(4):967-73
pubmed: 11035348
Annu Rev Virol. 2016 Sep 29;3(1):555-572
pubmed: 27618637
Nat Immunol. 2011 May;12(5):383-90
pubmed: 21502992
BMC Syst Biol. 2014 Jun 12;8:66
pubmed: 24923486
Trends Microbiol. 2011 Jan;19(1):33-9
pubmed: 21050765