A novel histopathological scoring system for patients with oral squamous cell carcinoma.


Journal

Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 11 09 2018
accepted: 11 01 2019
pubmed: 24 1 2019
medline: 18 12 2019
entrez: 24 1 2019
Statut: ppublish

Résumé

Tumor invasion into blood and/or lymphatic vessels, perineural invasion, and histopathological grading are evaluated to assess the biological aggressiveness of oral squamous cell carcinoma (OSCC). We aim to assess the prognostic impact of a novel scoring system, based upon the aforementioned histological parameters. Retrospective chart review of 334 patients with treatment-naive squamous cell carcinoma of the oral cavity. Statistical analysis was performed using univariate and multivariate analysis. Histological grade G1 or G2 were assigned 0 points and G3 or G4 1 point. Invasion of the lymphatic vessels, blood vessels, or perineural space was given 1 point. Zero points were given, when invasion was not detectable. The final score was conducted through addition of each parameter. Therefore, our scoring system ranged between 0 and 4 points. T-classification (p < 0.001), N-classification (p < 0.001), UICC stage (p < 0.001), extracapsular spread (p < 0.001), locoregional recurrence (p < 0.001), and overall survival (p < 0.001) were significantly associated with the OSCC-Histoscore. In multivariate analysis, T-classification (p = 0.001), N-classification (p = 0.039), resection margins (p = 0.038), and OSCC-Histoscore (p < 0.001) were independent prognostic markers for overall survival rate. Our presented OSCC-Histoscore serves as a strong independent prognostic parameter for 5-year overall survival (OS) and predicts OS better than T-classification, N-classification, and resection margins. Our presented histoscore improves prediction of the overall survival of patients with OSCC.

Identifiants

pubmed: 30673863
doi: 10.1007/s00784-019-02804-4
pii: 10.1007/s00784-019-02804-4
doi:

Types de publication

Journal Article

Langues

eng

Pagination

3759-3765

Références

Head Neck. 2002 Jun;24(6):513-20
pubmed: 12112547
Arch Otolaryngol Head Neck Surg. 1989 Nov;115(11):1304-9
pubmed: 2803710
SADJ. 2012 May;67(4):175-8
pubmed: 23198353
Int J Cancer. 2005 Mar 1;113(6):899-910
pubmed: 15515019
J Craniomaxillofac Surg. 2013 Jan;41(1):22-7
pubmed: 22727901
Hum Pathol. 1986 Apr;17(4):346-54
pubmed: 3957335
Head Neck Surg. 1980 Sep-Oct;3(1):2-7
pubmed: 7410099
CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49
pubmed: 19474385
J Surg Oncol. 2002 Jul;80(3):119-20
pubmed: 12115792
J Craniomaxillofac Surg. 2014 Dec;42(8):1572-6
pubmed: 24636353
Scand J Dent Res. 1987 Jun;95(3):229-49
pubmed: 3299675
Laryngoscope. 1999 May;109(5):795-9
pubmed: 10334233
J Craniomaxillofac Surg. 2015 Nov;43(9):1899-905
pubmed: 26447027
Oral Oncol. 2017 Sep;72:48-55
pubmed: 28797461
Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):913-8
pubmed: 19215825
Am J Surg Pathol. 2010 May;34(5):676-88
pubmed: 20414102
Oral Oncol. 2012 Apr;48(4):320-4
pubmed: 22178206
Br J Oral Maxillofac Surg. 1999 Jun;37(3):187-93
pubmed: 10454025
Oncology (Williston Park). 1990 Dec;4(12):39-42; discussion 42, 45-6
pubmed: 2149038
Head Neck. 2017 Dec;39(12):2488-2493
pubmed: 28981183
Acta Radiol Ther Phys Biol. 1975 Oct;14(5):465-74
pubmed: 1202925
J Craniomaxillofac Surg. 2017 Oct;45(10):1749-1753
pubmed: 28823597
Laryngoscope. 1995 Jul;105(7 Pt 1):728-33
pubmed: 7603278
Br J Cancer. 2006 Jun 5;94(11):1643-9
pubmed: 16670715
J Craniomaxillofac Surg. 2017 Dec;45(12):2092-2096
pubmed: 29033003
Acta Radiol Ther Phys Biol. 1973 Feb;12(1):1-8
pubmed: 4725642
J Craniomaxillofac Surg. 2017 Jul;45(7):1058-1061
pubmed: 28529103
Virchows Arch. 2010 May;456(5):473-82
pubmed: 20393745
Arch Otolaryngol Head Neck Surg. 1994 Dec;120(12):1370-4
pubmed: 7980903
Crit Rev Oral Biol Med. 2001;12(1):55-63
pubmed: 11349962
Acta Otolaryngol. 1975 Jan-Feb;79(1-2):146-54
pubmed: 1146534
Anticancer Res. 1998 Nov-Dec;18(6B):4757-64
pubmed: 9891553
Clin Otolaryngol Allied Sci. 1983 Jun;8(3):197-203
pubmed: 6883783

Auteurs

Ali-Farid Safi (AF)

Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany. asafi@outlook.de.
Center for Integrated Oncology Cologne-Bonn, Cologne, Germany. asafi@outlook.de.

Kathrin Grochau (K)

Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.
Center for Integrated Oncology Cologne-Bonn, Cologne, Germany.

Uta Drebber (U)

Center for Integrated Oncology Cologne-Bonn, Cologne, Germany.
Department for Pathology, University of Cologne, Cologne, Germany.

Volker Schick (V)

Center for Integrated Oncology Cologne-Bonn, Cologne, Germany.
Department for Anesthesiology and Intensive Care, University of Cologne, Cologne, Germany.

Oliver Thiele (O)

Department for Oral and Maxillofacial Plastic Surgery, Klinikum Ludwigshafen, Ludwigshafen, Germany.

Tim Backhaus (T)

Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.
Center for Integrated Oncology Cologne-Bonn, Cologne, Germany.

Hans-Joachim Nickenig (HJ)

Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.
Center for Integrated Oncology Cologne-Bonn, Cologne, Germany.

Joachim E Zöller (JE)

Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.
Center for Integrated Oncology Cologne-Bonn, Cologne, Germany.

Matthias Kreppel (M)

Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany.
Center for Integrated Oncology Cologne-Bonn, Cologne, Germany.

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