Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat.
Alpha-gal
Carbohydrate
Food allergy
Red meat allergy
Tick
Journal
Current allergy and asthma reports
ISSN: 1534-6315
Titre abrégé: Curr Allergy Asthma Rep
Pays: United States
ID NLM: 101096440
Informations de publication
Date de publication:
23 01 2019
23 01 2019
Historique:
entrez:
24
1
2019
pubmed:
24
1
2019
medline:
16
1
2020
Statut:
epublish
Résumé
The alpha-Gal (α-Gal) syndrome is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-alpha-1,3-galactose (α-Gal). In this article, we review the presence of α-Gal in food and non-food sources; we discuss the evolutionary context of the antibody response to α-Gal and highlight immune responses to α-Gal and other carbohydrates. IgE antibodies have been associated with delayed allergy to red meat. In addition to food, drugs, and other products of animal origin are increasingly perceived as a risk for patients sensitized to α-Gal. The link between tick bites and anti-α-Gal IgE-antibody production that has been established first by epidemiological studies has now been confirmed in mouse models. The anti-α-Gal immune response is complex and characterized by a unique feature. IgM and IgG antibodies have been found to confer protection against pathogens whereas the IgE-response to α-Gal is detrimental and causes severe reactions upon exposure to mammalian meat and other products.
Identifiants
pubmed: 30673913
doi: 10.1007/s11882-019-0835-9
pii: 10.1007/s11882-019-0835-9
pmc: PMC6344609
doi:
Substances chimiques
Galactose
X2RN3Q8DNE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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