Elevated Microdamage Spatially Correlates with Stress in Metastatic Vertebrae.
Backscatter electron imaging
Barium sulfate staining
Bone quality
Finite element analysis
Micro computed tomography
Microdamage
Vertebral metastasis
Journal
Annals of biomedical engineering
ISSN: 1573-9686
Titre abrégé: Ann Biomed Eng
Pays: United States
ID NLM: 0361512
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
03
08
2018
accepted:
11
12
2018
pubmed:
24
1
2019
medline:
27
6
2019
entrez:
24
1
2019
Statut:
ppublish
Résumé
Metastasis of cancer to the spine impacts bone quality. This study aims to characterize vertebral microdamage secondary to metastatic disease considering the pattern of damage and its relationship to stress and strain under load. Osteolytic and mixed osteolytic/osteoblastic vertebral metastases were produced in athymic rats via HeLa cervical or canine Ace-1 prostate cancer cell inoculation, respectively. After 21 days, excised motion segments (T12-L2) were µCT scanned, stained with BaSO
Identifiants
pubmed: 30673956
doi: 10.1007/s10439-018-02188-8
pii: 10.1007/s10439-018-02188-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
980-989Subventions
Organisme : Canadian Institutes of Health Research
ID : MOP125886
Pays : Canada
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