TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension.

Bone Marrow Cells Calcium Calcium Signaling / physiology Cell-Matrix Junctions / metabolism Cellular Microenvironment Collagen / biosynthesis Extracellular Matrix Focal Adhesions Humans Mesenchymal Stem Cells / metabolism TRPV Cation Channels / metabolism Vinculin / metabolism
calcium fibrocartilage mechanobiology mechanotransduction tendon

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
05 02 2019
Historique:
pubmed: 25 1 2019
medline: 13 4 2019
entrez: 25 1 2019
Statut: ppublish

Résumé

Microarchitectural cues drive aligned fibrillar collagen deposition in vivo and in biomaterial scaffolds, but the cell-signaling events that underlie this process are not well understood. Utilizing a multicellular patterning model system that allows for observation of intracellular signaling events during collagen matrix assembly, we investigated the role of calcium (Ca

Identifiants

DOI: 10.1073/pnas.1811095116 PMID: 30674675 PMC: PMC6369759
pubmed: 30674675
pii: 1811095116
doi: 10.1073/pnas.1811095116
pmc: PMC6369759
doi:

Substances chimiques

TRPV Cation Channels 0
TRPV4 protein, human 0
VCL protein, human 0
Vinculin 125361-02-6
Collagen 9007-34-5
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1992-1997

Subventions

Organisme : NIAMS NIH HHS
ID : K08 AR059784
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR073752
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR048852
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG046927
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR048182
Pays : United States
Organisme : NIAMS NIH HHS
ID : P01 AR050245
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015768
Pays : United States
Organisme : NIAMS NIH HHS
ID : F32 AR065888
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR057235
Pays : United States
Organisme : NIAMS NIH HHS
ID : R03 AR065764
Pays : United States

Déclaration de conflit d'intérêts

Conflict of interest statement: F.G. and W.L. have filed patents on inhibitors of TRPV4.

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Auteurs

Christopher L Gilchrist (CL)

Department of Biomedical Engineering, Duke University, Durham, NC 27701.

Holly A Leddy (HA)

Department of Biomedical Engineering, Duke University, Durham, NC 27701.

Laurel Kaye (L)

Department of Biomedical Engineering, Duke University, Durham, NC 27701.

Natasha D Case (ND)

Department of Biomedical Engineering, Saint Louis University, St. Louis, MO 63103.

Katheryn E Rothenberg (KE)

Department of Biomedical Engineering, Duke University, Durham, NC 27701.
ORCID: 0000-0002-8191-7528

Dianne Little (D)

Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907.
Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907.

Wolfgang Liedtke (W)

Department of Neurology, Duke University Medical Center, Durham, NC 27710.

Brenton D Hoffman (BD)

Department of Biomedical Engineering, Duke University, Durham, NC 27701; brenton.hoffman@duke.edu guilak@wustl.edu.

Farshid Guilak (F)

Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO 63130; brenton.hoffman@duke.edu guilak@wustl.edu.
Shriners Hospitals for Children-St. Louis, St. Louis, MO 63110.
ORCID: 0000-0001-7380-0330

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › TRPV4-mediated calcium signaling in...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › TRPV4-mediated calcium signaling in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › TRPV4-mediated calcium signaling in...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions cellule-matrice › TRPV4-mediated calcium signaling in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › TRPV4-mediated calcium signaling in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › TRPV4-mediated calcium signaling in...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Matrice extracellulaire › TRPV4-mediated calcium signaling in...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions cellule-matrice › Contacts focaux › TRPV4-mediated calcium signaling in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › TRPV4-mediated calcium signaling in...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › TRPV4-mediated calcium signaling in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › TRPV4-mediated calcium signaling in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Vinculine › TRPV4-mediated calcium signaling in...