Autophagic cell death restricts chromosomal instability during replicative crisis.
Autophagy
/ genetics
Carcinogenesis
/ genetics
Cell Cycle Checkpoints
Cell Line
Cell Proliferation
Chromatin
/ genetics
Chromosomal Instability
/ genetics
DNA Damage
/ genetics
Epithelial Cells
/ metabolism
Fibroblasts
/ metabolism
Humans
Membrane Proteins
/ metabolism
Nuclear Envelope
/ pathology
Nucleotidyltransferases
/ metabolism
Telomere
/ genetics
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
28
03
2018
accepted:
17
12
2018
pubmed:
25
1
2019
medline:
20
6
2019
entrez:
25
1
2019
Statut:
ppublish
Résumé
Replicative crisis is a senescence-independent process that acts as a final barrier against oncogenic transformation by eliminating pre-cancerous cells with disrupted cell cycle checkpoints
Identifiants
pubmed: 30675059
doi: 10.1038/s41586-019-0885-0
pii: 10.1038/s41586-019-0885-0
pmc: PMC6557118
mid: NIHMS1018342
doi:
Substances chimiques
Chromatin
0
Membrane Proteins
0
STING1 protein, human
0
Nucleotidyltransferases
EC 2.7.7.-
cGAS protein, human
EC 2.7.7.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
659-663Subventions
Organisme : NCI NIH HHS
ID : R01 CA234047
Pays : United States
Organisme : NIH HHS
ID : GM087476
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM087476
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014195
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA174942
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227934
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
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