Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico-pathological and molecular (next generation sequencing) study of 22 cases.

NGS endometrial carcinoma endometrioid carcinoma ovarian carcinoma synchronous tumors

Journal

Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236

Informations de publication

Date de publication:
Feb 2019
Historique:
received: 13 08 2018
accepted: 05 12 2018
entrez: 25 1 2019
pubmed: 25 1 2019
medline: 25 1 2019
Statut: ppublish

Résumé

The criteria for distinction between independent primary tumors and metastasis from one site to the other in synchronous endometrioid endometrial and ovarian carcinoma (SEO) has been a matter of dispute for a long time. In our study we performed a comprehensive clinico-pathological and molecular analysis of 22 cases of SEO. Based on conventional clinico-pathological criteria the cases were classified as independent primary tumors (10 cases) and metastasis from one location to the other (12 cases). All tumors were analyzed by NGS with a panel of 73 genes (219 kbp). Clonal origin was confirmed in all cases by at least one shared mutation in

Identifiants

pubmed: 30675285
doi: 10.3892/ol.2018.9855
pii: OL-0-0-9855
pmc: PMC6341770
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2207-2214

Références

Diagn Mol Pathol. 2001 Jun;10(2):116-22
pubmed: 11385321
Gynecol Oncol. 2001 Nov;83(2):355-62
pubmed: 11606097
Hum Pathol. 2002 Apr;33(4):421-8
pubmed: 12055677
Int J Gynecol Cancer. 2003 Jan-Feb;13(1):32-7
pubmed: 12631217
Diagn Mol Pathol. 2003 Jun;12(2):71-8
pubmed: 12766611
Gynecol Oncol. 2004 Aug;94(2):456-62
pubmed: 15297188
Hum Pathol. 2005 Jun;36(6):605-19
pubmed: 16021566
Breast Cancer Res. 2005;7(5):R728-36
pubmed: 16168118
Int J Oncol. 2005 Dec;27(6):1519-26
pubmed: 16273207
Asian Pac J Cancer Prev. 2006 Apr-Jun;7(2):234-8
pubmed: 16839215
Cancer. 1991 Dec 1;68(11):2455-9
pubmed: 1933783
Eur J Hum Genet. 2011 Mar;19(3):300-6
pubmed: 21119707
Breast Cancer Res Treat. 2012 Jan;131(1):89-97
pubmed: 21344236
J Mol Diagn. 2012 Jan;14(1):56-60
pubmed: 22026957
J Gynecol Oncol. 2011 Dec;22(4):239-43
pubmed: 22247800
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
Oncol Lett. 2013 Jan;5(1):267-270
pubmed: 23255933
Gynecol Oncol. 2013 Dec;131(3):624-8
pubmed: 24051220
Int J Gynecol Pathol. 2014 May;33(3):274-81
pubmed: 24681739
Nature. 2014 Sep 11;513(7517):202-9
pubmed: 25079317
Int J Gynecol Cancer. 2015 Mar;25(3):440-6
pubmed: 25695547
Prz Menopauzalny. 2014 Mar;13(1):64-9
pubmed: 26327831
J Obstet Gynaecol Res. 2015 Nov;41(11):1813-9
pubmed: 26369625
Pathol Oncol Res. 2016 Jul;22(3):523-30
pubmed: 26685938
J Natl Cancer Inst. 2016 Feb 01;108(6):djv427
pubmed: 26832770
J Natl Cancer Inst. 2016 Feb 01;108(6):djv428
pubmed: 26832771
Eur J Obstet Gynecol Reprod Biol. 2016 May;200:113-6
pubmed: 27017531
Gynecol Oncol. 2016 Oct;143(1):60-67
pubmed: 27498588
BMC Cancer. 2017 Jan 19;17(1):66
pubmed: 28103826
Cancer Causes Control. 2017 May;28(5):447-457
pubmed: 28194593
Gynecol Oncol. 2017 Dec;147(3):558-564
pubmed: 28986093
Cold Spring Harb Mol Case Stud. 2017 Nov 21;3(6):null
pubmed: 29162652
Pathology. 2018 Feb;50(2):190-204
pubmed: 29241974
Int J Gynecol Cancer. 2018 May;28(4):704-712
pubmed: 29498984
Hum Pathol. 1985 Jan;16(1):28-34
pubmed: 2982713
Cancer. 1982 Jul 1;50(1):163-70
pubmed: 7083121
Am J Clin Pathol. 1996 Mar;105(3):350-9
pubmed: 8602617
Cancer. 1995 Aug 15;76(4):650-7
pubmed: 8625160
Int J Gynecol Pathol. 1997 Apr;16(2):143-8
pubmed: 9100068
Clin Cancer Res. 1998 Nov;4(11):2577-83
pubmed: 9829719

Auteurs

Nikola Hájková (N)

Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12800 Prague, Czech Republic.

Ivana Tichá (I)

Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12800 Prague, Czech Republic.

Jan Hojný (J)

Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12800 Prague, Czech Republic.

Kristýna Němejcová (K)

Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12800 Prague, Czech Republic.

Michaela Bártů (M)

Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12800 Prague, Czech Republic.

Romana Michálková (R)

Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12800 Prague, Czech Republic.

Michal Zikán (M)

Department of Obstetrics and Gynecology, Bulovka Hospital, First Faculty of Medicine, Charles University, 18081 Prague, Czech Republic.

David Cibula (D)

Department of Obstetrics and Gynecology, Oncogynecological Centre, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12000 Prague, Czech Republic.

Jan Laco (J)

The Fingerland Department of Pathology, Charles University Faculty of Medicine and University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic.

Tomáš Geryk (T)

The Fingerland Department of Pathology, Charles University Faculty of Medicine and University Hospital Hradec Kralove, 50005 Hradec Kralove, Czech Republic.

Gábor Méhes (G)

Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Pavel Dundr (P)

Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12800 Prague, Czech Republic.

Classifications MeSH