Circulating angiopoietin-like protein 2 levels are associated with decreased renal function in HIV
CKD-EPI
angiopoietin-like protein 2
cART
inflammation
renal function
Journal
Biomedical reports
ISSN: 2049-9434
Titre abrégé: Biomed Rep
Pays: England
ID NLM: 101613227
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
27
11
2018
accepted:
07
01
2019
entrez:
25
1
2019
pubmed:
25
1
2019
medline:
25
1
2019
Statut:
ppublish
Résumé
Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-infected individuals, even in the antiretroviral therapy (ART) era. Inflammatory cytokines and adipokines have been suggested to play a role in the development of CKD. The aim of the present study was to examine the circulating levels of a novel proinflammatory cytokine, angiopoietin-like protein 2 (ANGPTL2), in a cohort of 72 HIV-positive subjects on ART. HIV-positive patients were on cART for at least one year. Urine and blood samples were collected. Various factors were analyzed including body mass index (BMI), smoking, and presence/treatment for comorbidities such as diabetes. The estimated glomerular filtration rate was calculated by using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Plasma samples obtained were stored and used to measure sCD14 and ANGPTL2 levels. Data were presented as mean (± standard deviation) or median (interquartile range) for continuous variables. Categorical variables were expressed as number (%). Variables were compared using Student's t-test, Mann-Whitney test, or χ
Identifiants
pubmed: 30675354
doi: 10.3892/br.2019.1183
pii: BR-0-0-1183
pmc: PMC6341407
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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