The University of California, San Francisco Documentation System for Retinoblastoma: Preparing to Improve Staging Methods for This Disease.
Prognosis
Retinoblastoma
Treatment
Journal
Ocular oncology and pathology
ISSN: 2296-4681
Titre abrégé: Ocul Oncol Pathol
Pays: Switzerland
ID NLM: 101656139
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
13
02
2018
revised:
02
03
2018
entrez:
25
1
2019
pubmed:
25
1
2019
medline:
25
1
2019
Statut:
ppublish
Résumé
Current retinoblastoma staging systems do not adequately describe the disease, especially in eyes with multiple tumors. The aims of this study were to develop methods for documenting individual tumors and to score disease burden over time. A coding system was devised to describe each tumor according to affected eye, meridian, anteroposterior location, activity, growth pattern, type of seed, and treatment. A scoring system for quantifying disease burden was developed, taking account of tumor number, size, spread, and secondary effects on the eye. Our coding system allowed contemporaneous tumor documentation, producing datasets that enabled generation of fundus diagrams, Kaplan-Meier curves, and tables summarizing disease progression in individual tumors and eyes. Our data showed disparities between ocular and tumor documentation, e.g., indicating earlier tumor development in the left eye but younger age at presentation if disease was worse in the right eye. Actuarial rates of local treatment failure were lower when individual tumors were analyzed than when data were reported in terms of whole eyes. Our methods for documenting individual retinoblastomas have facilitated the review of patients' progress in our routine practice and may provide data that could be used to refine retinoblastoma classifications in the future.
Sections du résumé
BACKGROUND/AIMS
OBJECTIVE
Current retinoblastoma staging systems do not adequately describe the disease, especially in eyes with multiple tumors. The aims of this study were to develop methods for documenting individual tumors and to score disease burden over time.
METHODS
METHODS
A coding system was devised to describe each tumor according to affected eye, meridian, anteroposterior location, activity, growth pattern, type of seed, and treatment. A scoring system for quantifying disease burden was developed, taking account of tumor number, size, spread, and secondary effects on the eye.
RESULTS
RESULTS
Our coding system allowed contemporaneous tumor documentation, producing datasets that enabled generation of fundus diagrams, Kaplan-Meier curves, and tables summarizing disease progression in individual tumors and eyes. Our data showed disparities between ocular and tumor documentation, e.g., indicating earlier tumor development in the left eye but younger age at presentation if disease was worse in the right eye. Actuarial rates of local treatment failure were lower when individual tumors were analyzed than when data were reported in terms of whole eyes.
CONCLUSION
CONCLUSIONS
Our methods for documenting individual retinoblastomas have facilitated the review of patients' progress in our routine practice and may provide data that could be used to refine retinoblastoma classifications in the future.
Identifiants
pubmed: 30675475
doi: 10.1159/000488147
pii: oop-0005-0036
pmc: PMC6341334
doi:
Types de publication
Journal Article
Langues
eng
Pagination
36-45Subventions
Organisme : NEI NIH HHS
ID : P30 EY002162
Pays : United States
Références
Curr Opin Ophthalmol. 2006 Jun;17(3):228-34
pubmed: 16794434
J Comp Neurol. 1990 Feb 22;292(4):497-523
pubmed: 2324310
Nature. 2014 Oct 16;514(7522):385-8
pubmed: 25252974
Ophthalmology. 2015 Jun;122(6):1173-9
pubmed: 25795478
CA Cancer J Clin. 2016 Sep;66(5):370-4
pubmed: 26784705
Ophthalmic Genet. 1994 Sep-Dec;15(3-4):101-6
pubmed: 7749662