Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders.


Journal

Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818

Informations de publication

Date de publication:
08 2019
Historique:
received: 30 08 2018
revised: 24 12 2018
pubmed: 25 1 2019
medline: 14 4 2020
entrez: 25 1 2019
Statut: ppublish

Résumé

Pomegranate (Punica granatum Linn) is used in the prevention and treatment of metabolic syndrome in recent decades. Imbalances in lipid metabolism are profound features of metabolic disorders. In vivo and in vitro studies have shown that extracts of different pomegranate fractions (peels, flowers, juice, and seeds) regulate lipid metabolism in metabolic-disorder-associated diseases such as atherosclerosis, nonalcoholic fatty liver disease, and type 2 diabetes, helping to alleviate the development of diseases. Amelioration of oxidative stress and the inflammatory response is considered an important reason underlying the regulation of lipid metabolism by pomegranate extracts. Mitochondria, the major cellular site for lipid oxidation, are strongly associated with cellular oxidative and inflammatory status and are likely to be a target for pomegranate extract action. This review summarizes the main findings about the effects of different pomegranate fraction extracts on lipid metabolism in metabolic-disorder-associated diseases and analyses how pomegranate extracts achieve their effects. Furthermore, it also provides an important basis for the research and development of pomegranate-related nutrients or drugs.

Identifiants

pubmed: 30677224
doi: 10.1002/mnfr.201800773
doi:

Substances chimiques

Plant Extracts 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1800773

Informations de copyright

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Auteurs

Chen Hou (C)

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, 710119, China.
University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an, 710119, China.

Weimin Zhang (W)

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, 710119, China.
University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an, 710119, China.
School of Public Health, Shaanxi University of Chinese Medicine, Xianyang, 712046, China.

Jianke Li (J)

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, 710119, China.
University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an, 710119, China.
National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Xi'an, 710119, China.

Lin Du (L)

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, 710119, China.
University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an, 710119, China.

Ou Lv (O)

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, 710119, China.
University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an, 710119, China.

Shengjuan Zhao (S)

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, 710119, China.
University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an, 710119, China.

Jia Li (J)

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, 710119, China.
University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an, 710119, China.

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