Carbonic Anhydrase Inhibitors of Different Structures Dilate Pre-Contracted Porcine Retinal Arteries.
carbonic anhydrase
vascular tone
vasodilation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Jan 2019
22 Jan 2019
Historique:
received:
12
12
2018
revised:
13
01
2019
accepted:
17
01
2019
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
14
5
2019
Statut:
epublish
Résumé
Carbonic anhydrase inhibitors (CAIs), such as dorzolamide (DZA), are used as anti-glaucoma drugs to lower intraocular pressure, but it has been found that some of these drugs act as vasodilators of retinal arteries. The exact mechanism behind the vasodilatory effect is not yet clear. Here we have addressed the issue by using small vessel myography to examine the effect of CAIs of the sulfonamide and coumarin type on the wall tension in isolated segments of porcine retinal arteries. Vessels were pre-contracted by the prostaglandin analog U-46619, and CAIs with varying affinity for five different carbonic anhydrase (CA) isoenzymes found in human tissue tested. We found that all compounds tested cause a vasodilation of pre-contracted retinal arteries, but with varying efficacy, as indicated by the calculated mean EC
Identifiants
pubmed: 30678227
pii: ijms20030467
doi: 10.3390/ijms20030467
pmc: PMC6387369
pii:
doi:
Substances chimiques
Carbonic Anhydrase Inhibitors
0
Sulfonamides
0
Thiophenes
0
dorzolamide
9JDX055TW1
Carbonic Anhydrases
EC 4.2.1.1
Benzolamide
FC5AAH89R5
Acetazolamide
O3FX965V0I
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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