Circulating MiRNA-195-5p and -451a in Transient and Acute Ischemic Stroke Patients in an Emergency Department.
acute ischemic stroke
emergency
miRNA
transient ischemic attack
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
22 Jan 2019
22 Jan 2019
Historique:
received:
12
12
2018
revised:
14
01
2019
accepted:
20
01
2019
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
27
1
2019
Statut:
epublish
Résumé
We have evaluated circulating miRNAs (-195-5p and -451a) in subjects with acute ischemic stroke (AIS) and in patients with transient ischemic attack (TIA). In this study, 18 subjects with AIS and 18 patients with TIA were enrolled and examined at admission (T0) and at 24 h and 48 h after admission, and compared to 20 controls (C). At T0, circulating miRNA-195-5p and -451a were significantly upregulated in both AIS and TIA patients, compared to C. We also observed a progressive reduction of circulating miRNA levels at 24 h and 48 h in both AIS and TIA patients. Hypoxia inducible factor 1alpha (HIF-1α) serum level was significantly increased at T0, in both AIS and TIA patients, in comparison to C (both
Identifiants
pubmed: 30678250
pii: jcm8020130
doi: 10.3390/jcm8020130
pmc: PMC6406765
pii:
doi:
Types de publication
Journal Article
Langues
eng
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