HR-MAS NMR Based Quantitative Metabolomics in Breast Cancer.
HR MAS
NMR
breast cancer
metabolomics
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
22 Jan 2019
22 Jan 2019
Historique:
received:
16
12
2018
revised:
17
01
2019
accepted:
18
01
2019
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
27
1
2019
Statut:
epublish
Résumé
High resolution magic-angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy is increasingly used for profiling of breast cancer tissue, delivering quantitative information for approximately 40 metabolites. One unique advantage of the method is that it can be used to analyse intact tissue, thereby requiring only minimal sample preparation. Importantly, since the method is non-destructive, it allows further investigations of the same specimen using for instance transcriptomics. Here, we discuss technical aspects critical for a successful analysis - including sample handling, measurement conditions, pulse sequences for one- and two dimensional analysis, and quantification methods - and summarize available studies, with a focus on significant associations of metabolite levels with clinically relevant parameters.
Identifiants
pubmed: 30678289
pii: metabo9020019
doi: 10.3390/metabo9020019
pmc: PMC6410210
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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