Cationic Niosomes as Non-Viral Vehicles for Nucleic Acids: Challenges and Opportunities in Gene Delivery.
antisense oligonucleotides
aptamers
cationic lipids
cationic niosomes
gene delivery
plasmids
small interference RNA
therapy
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
22 Jan 2019
22 Jan 2019
Historique:
received:
19
12
2018
revised:
16
01
2019
accepted:
17
01
2019
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
27
1
2019
Statut:
epublish
Résumé
Cationic niosomes have become important non-viral vehicles for transporting a good number of small drug molecules and macromolecules. Growing interest shown by these colloidal nanoparticles in therapy is determined by their structural similarities to liposomes. Cationic niosomes are usually obtained from the self-assembly of non-ionic surfactant molecules. This process can be governed not only by the nature of such surfactants but also by others factors like the presence of additives, formulation preparation and properties of the encapsulated hydrophobic or hydrophilic molecules. This review is aimed at providing recent information for using cationic niosomes for gene delivery purposes with particular emphasis on improving the transportation of antisense oligonucleotides (ASOs), small interference RNAs (siRNAs), aptamers and plasmids (pDNA).
Identifiants
pubmed: 30678296
pii: pharmaceutics11020050
doi: 10.3390/pharmaceutics11020050
pmc: PMC6409589
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : CTQ2017-84415-R
Organisme : Ministerio de Ciencia y Tecnología
ID : MAT2015-69967-C3-1R
Organisme : Ministerio de Ciencia e Innovación
ID : CTQ2017-88948-P
Organisme : Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina
ID : CB06_01_1028
Organisme : Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina
ID : CB06_01_0019
Organisme : Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina
ID : CB06_01_1053
Organisme : Ikerbasque, Basque Foundation for Science
ID : CGIC10/172
Organisme : Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya
ID : 2017/SGR/114
Organisme : Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya
ID : 2017/SGR/670
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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