CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere.
CENP-A
CUL4A-RBX1- COPS8 E3 ligase
centromere
centromere identity
dimerization
epigenetics
kinetochore
lysine 124 (K124), neocentromere
ubiquitylation
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
22 Jan 2019
22 Jan 2019
Historique:
received:
14
12
2018
revised:
15
01
2019
accepted:
20
01
2019
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
24
4
2019
Statut:
epublish
Résumé
The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centromere protein A (CENP-A), in centromeric nucleosomes. However, the precise mechanisms of deposition, maintenance, and inheritance of CENP-A at centromeres are unclear. We have reported that CENP-A deposition requires ubiquitylation of CENP-A lysine 124 mediated by the E3 ligase activity of Cullin 4A (CUL4A)-RING-box protein 1 (RBX1)-COP9 signalsome complex subunit 8 (COPS8). We have proposed a model of inheritance for CENP-A ubiquitylation, through dimerization between rounds of cell divisions, that maintains the position of centromeres.
Identifiants
pubmed: 30678315
pii: molecules24030402
doi: 10.3390/molecules24030402
pmc: PMC6384693
pii:
doi:
Substances chimiques
Centromere Protein A
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R21 CA205659
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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