Human Polyclonal Antibodies Produced from Transchromosomal Bovine Provides Prophylactic and Therapeutic Protections Against Zika Virus Infection in
Animals
Animals, Genetically Modified
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
Cattle
Cricetinae
Disease Models, Animal
Female
Gene Knockout Techniques
Humans
Immunization, Passive
Male
STAT2 Transcription Factor
/ genetics
Testis
/ pathology
Zika Virus
Zika Virus Infection
/ prevention & control
STAT2 KO hamster
Zika virus
testis
therapeutic
transchromosomal bovine antibody
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
22 01 2019
22 01 2019
Historique:
received:
02
12
2018
revised:
18
01
2019
accepted:
19
01
2019
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
21
6
2019
Statut:
epublish
Résumé
Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain⁻Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZIKV infection. Here, we report that ZIKV-specific human polyclonal antibodies (SAB-155), elicited in transchromosomal bovine (TcB), provide significant protection from infection by ZIKV in
Identifiants
pubmed: 30678320
pii: v11020092
doi: 10.3390/v11020092
pmc: PMC6410148
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
STAT2 Transcription Factor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : 1R21NS09013301A1
Pays : United States
Organisme : NIH HHS
ID : 5R21NS08840002
Pays : United States
Organisme : NIH HHS
ID : 5R33AI101483
Pays : United States
Organisme : NIH HHS
ID : HHSN272201000039I
Pays : United States
Organisme : NIH HHS
ID : HHSN27200018
Pays : United States
Organisme : NIH HHS
ID : 1R41OD021979-01
Pays : United States
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