Retrobulbar Sinus Injection of Doxorubicin is More Efficient Than Lateral Tail Vein Injection at Inducing Experimental Nephrotic Syndrome in Mice: A Pilot Study.
3R
doxorubicin
experimental nephrotic syndrome
lateral tail vein injection
mice
refinement
retrobulbar sinus injection
Journal
Laboratory animals
ISSN: 1758-1117
Titre abrégé: Lab Anim
Pays: England
ID NLM: 0112725
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
pubmed:
27
1
2019
medline:
18
3
2020
entrez:
26
1
2019
Statut:
ppublish
Résumé
Doxorubicin-induced nephropathy in mice is a model for studying experimental nephrotic syndrome. It corresponds to puromycin aminonucleoside nephrosis in rats. In this model, susceptible 129 S1/SvImJ mice are administered a rapid intravenous injection that can be accomplished via either the lateral tail vein or the retrobulbar sinus. Because doxorubicin is a highly toxic substance, extravasation must be avoided during the administration of the intravenous injection to prevent the development of large necrotizing lesions and exacerbation of the animals' stress. In the present study, we compared the safety and stress of these two injection routes by using histopathological analyses of the animals' orbital cavities or tails, respectively. The injection of 14.5 µg/g body weight doxorubicin into the mice's lateral tail veins (
Identifiants
pubmed: 30678519
doi: 10.1177/0023677218824382
pmc: PMC7238670
doi:
Substances chimiques
Doxorubicin
80168379AG
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
564-576Références
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