Silk fibroin protein modified acellular dermal matrix for tissue repairing and regeneration.
Acellular Dermis
Animals
Biocompatible Materials
/ chemistry
Female
Fibroblasts
Fibroins
/ chemistry
Goats
Male
Materials Testing
Mice
Microscopy, Electron, Scanning
/ methods
Regeneration
/ physiology
Skin Physiological Phenomena
Spectroscopy, Fourier Transform Infrared
Tissue Engineering
Tissue Scaffolds
Wound Healing
/ physiology
Acellular
Extracellular matrix
Scaffold
Silk fibroin
Tissue engineering
Wound healing
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
21
06
2018
revised:
13
11
2018
accepted:
11
12
2018
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
14
6
2019
Statut:
ppublish
Résumé
Worldwide the demand of skin-graft has been increasing day by day, for these different biomaterials and techniques have been used. In the present study, we have fabricated Silk Fibroin (SF) modified hybrid acellular goat-dermal matrix (SF-AGDM) by modifying the AGDM in different concentration SF- 5, 10, 15%, for enhancing the wound healing process. The grafts (AGDM and SF-AGDM) were evaluated for skin tissue regeneration by subjecting it through physical, chemical and biological characterization. SLS analysis showed the molecular weight of SF was 10,000 Da. Here, we found that SF-AGDM modified with low concentration of SF showed good porosity 78.56 ± 14.30% and pore size 74.69 ± 28.66 μm as similar to the AGDM. FTIR analysis showed the shifting of NH stretching (3400-3600 cm
Identifiants
pubmed: 30678917
pii: S0928-4931(18)31464-4
doi: 10.1016/j.msec.2018.12.038
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Fibroins
9007-76-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
313-324Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.