Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 01 2019
24 01 2019
Historique:
received:
17
07
2018
accepted:
26
11
2018
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
11
8
2020
Statut:
epublish
Résumé
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease where substantial heterogeneity in clinical presentation urgently requires a better stratification of patients for the development of drug trials and clinical care. In this study we explored stratification through a crowdsourcing approach, the DREAM Prize4Life ALS Stratification Challenge. Using data from >10,000 patients from ALS clinical trials and 1479 patients from community-based patient registers, more than 30 teams developed new approaches for machine learning and clustering, outperforming the best current predictions of disease outcome. We propose a new method to integrate and analyze patient clusters across methods, showing a clear pattern of consistent and clinically relevant sub-groups of patients that also enabled the reliable classification of new patients. Our analyses reveal novel insights in ALS and describe for the first time the potential of a crowdsourcing to uncover hidden patient sub-populations, and to accelerate disease understanding and therapeutic development.
Identifiants
pubmed: 30679616
doi: 10.1038/s41598-018-36873-4
pii: 10.1038/s41598-018-36873-4
pmc: PMC6345935
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
690Investigateurs
Rached Alkallas
(R)
Catalina Anghel
(C)
Jeanne Avril
(J)
Jaume Bacardit
(J)
Barbara Balser
(B)
John Balser
(J)
Yoav Bar-Sinai
(Y)
Noa Ben-David
(N)
Eyal Ben-Zion
(E)
Robin Bliss
(R)
Jialu Cai
(J)
Anatoly Chernyshev
(A)
Jung-Hsien Chiang
(JH)
Davide Chicco
(D)
Bhavna Ahuja Nicole Corriveau
(BAN)
Junqiang Dai
(J)
Yash Deshpande
(Y)
Eve Desplats
(E)
Joseph S Durgin
(JS)
Shadrielle Melijah G Espiritu
(SMG)
Fan Fan
(F)
Philippe Fevrier
(P)
Brooke L Fridley
(BL)
Adam Godzik
(A)
Agnieszka Golińska
(A)
Jonathan Gordon
(J)
Stefan Graw
(S)
Yuelong Guo
(Y)
Tim Herpelinck
(T)
Julia Hopkins
(J)
Barbara Huang
(B)
Jeremy Jacobsen
(J)
Samad Jahandideh
(S)
Jouhyun Jeon
(J)
Wenkai Ji
(W)
Kenneth Jung
(K)
Alex Karanevich
(A)
Devin C Koestler
(DC)
Michael Kozak
(M)
Christoph Kurz
(C)
Christopher Lalansingh
(C)
Thomas Larrieu
(T)
Nicola Lazzarini
(N)
Boaz Lerner
(B)
Wojciech Lesinski
(W)
Xiaotao Liang
(X)
Xihui Lin
(X)
Jarrett Lowe
(J)
Lester Mackey
(L)
Richard Meier
(R)
Wenwen Min
(W)
Krzysztof Mnich
(K)
Violette Nahmias
(V)
Janelle Noel-MacDonnell
(J)
Adrienne O'Donnell
(A)
Susan Paadre
(S)
Ji Park
(J)
Aneta Polewko-Klim
(A)
Rama Raghavan
(R)
Witold Rudnicki
(W)
Ehsan Saghapour
(E)
Jean-Bernard Salomond
(JB)
Kris Sankaran
(K)
Dorota Sendorek
(D)
Vatsal Sharan
(V)
Yu-Jia Shiah
(YJ)
Jean-Karl Sirois
(JK)
Dinithi N Sumanaweera
(DN)
Joseph Usset
(J)
Yeeleng S Vang
(YS)
Celine Vens
(C)
Dave Wadden
(D)
David Wang
(D)
Wing Chung Wong
(WC)
Xiaohui Xie
(X)
Zhiqing Xu
(Z)
Hsih-Te Yang
(HT)
Xiang Yu
(X)
Haichen Zhang
(H)
Li Zhang
(L)
Shihua Zhang
(S)
Shanfeng Zhu
(S)
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