Attenuation of murine sclerodermatous models by the selective S1P
Animals
B-Lymphocytes
/ cytology
Cell Count
Collagen
/ biosynthesis
Cytokines
/ genetics
Disease Models, Animal
Down-Regulation
/ drug effects
Female
Fibroblasts
/ drug effects
Fibrosis
Graft vs Host Disease
/ drug therapy
Male
Mice
Oxadiazoles
/ metabolism
Propylene Glycols
/ metabolism
RNA, Messenger
/ genetics
Scleroderma, Systemic
/ drug therapy
Skin
/ drug effects
Sphingosine-1-Phosphate Receptors
/ metabolism
T-Lymphocytes, Regulatory
/ cytology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 01 2019
24 01 2019
Historique:
received:
03
08
2018
accepted:
30
11
2018
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
8
8
2020
Statut:
epublish
Résumé
Sphingosine-1-phosphate (S1P), a lipid mediator, regulates lymphocyte migration between lymphoid tissue and blood. Furthermore, S1P participates in several physiological phenomena including angiogenesis, inflammation, immune regulation, and neurotransmitter release. Moreover, S1P/S1P receptor signaling involves in systemic sclerosis (SSc) pathogenesis. This study aimed to investigate whether the selective S1P
Identifiants
pubmed: 30679645
doi: 10.1038/s41598-018-37074-9
pii: 10.1038/s41598-018-37074-9
pmc: PMC6345830
doi:
Substances chimiques
Cytokines
0
Oxadiazoles
0
Propylene Glycols
0
RNA, Messenger
0
Sphingosine-1-Phosphate Receptors
0
Collagen
9007-34-5
cenerimod
Y333RS1786
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
658Références
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