Celiac plexus block increases quality of life in patients with pancreatic cancer.
cancer pain
celiac plexus
neural therapy
palliative care
pancreatic cancer
plexus block
quality of life
Journal
Journal of pain research
ISSN: 1178-7090
Titre abrégé: J Pain Res
Pays: New Zealand
ID NLM: 101540514
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
27
1
2019
Statut:
epublish
Résumé
Pancreatic cancer is a malignant disease with a high mortality rate and severe pain that is challenging to manage. To reduce the excruciating abdominal pain, opioids and adjuvant agents are conventionally used. PRNCPB is a treatment of neural therapy. The number of studies assessing the effect on patients' QoL is limited and inconsistent. With this study, we intended to address this issue. A prospective nonrandomized study with a series of cases of unresectable pancreatic cancer was conducted. The study was performed at our pain clinic under real life conditions. A total number of 16 patients with severe abdominal pain were enrolled in the study all of whom had responded to combined systemic analgesic therapy inadequately and had intolerable side effects contraindicating further increase in dose. The efficacy of this invasive, palliative analgesic procedure was evaluated 35 days after PRNCPB was performed. Primary outcomes were changed in pain intensity using the VAS questionnaire. Secondary outcomes were improved in QoL using the SF-36 questionnaire. Changes in pain medications and adverse reactions were monitored. After PRNCPB patients experienced a significant decrease ( Detection, observation, and reporting bias can be estimated as moderate. Selection bias was not detected. Our results give preliminary evidence that PRNCPB might be helpful as an additional treatment to conventional pain management in end-stage pancreatic cancer patients. PRNCPB seems to improve QoL in these patients in a time frame of at least 5 weeks after intervention.
Sections du résumé
BACKGROUND
BACKGROUND
Pancreatic cancer is a malignant disease with a high mortality rate and severe pain that is challenging to manage. To reduce the excruciating abdominal pain, opioids and adjuvant agents are conventionally used.
OBJECTIVES
OBJECTIVE
PRNCPB is a treatment of neural therapy. The number of studies assessing the effect on patients' QoL is limited and inconsistent. With this study, we intended to address this issue.
STUDY DESIGN
METHODS
A prospective nonrandomized study with a series of cases of unresectable pancreatic cancer was conducted.
SETTING
METHODS
The study was performed at our pain clinic under real life conditions.
MATERIALS AND METHODS
METHODS
A total number of 16 patients with severe abdominal pain were enrolled in the study all of whom had responded to combined systemic analgesic therapy inadequately and had intolerable side effects contraindicating further increase in dose. The efficacy of this invasive, palliative analgesic procedure was evaluated 35 days after PRNCPB was performed. Primary outcomes were changed in pain intensity using the VAS questionnaire. Secondary outcomes were improved in QoL using the SF-36 questionnaire. Changes in pain medications and adverse reactions were monitored.
RESULTS
RESULTS
After PRNCPB patients experienced a significant decrease (
LIMITATIONS
CONCLUSIONS
Detection, observation, and reporting bias can be estimated as moderate. Selection bias was not detected.
CONCLUSION
CONCLUSIONS
Our results give preliminary evidence that PRNCPB might be helpful as an additional treatment to conventional pain management in end-stage pancreatic cancer patients. PRNCPB seems to improve QoL in these patients in a time frame of at least 5 weeks after intervention.
Identifiants
pubmed: 30679920
doi: 10.2147/JPR.S186659
pii: jpr-12-307
pmc: PMC6338112
doi:
Types de publication
Journal Article
Langues
eng
Pagination
307-315Déclaration de conflit d'intérêts
Disclosure The authors report no conflicts of interest in this work.
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