Small dense LDL cholesterol is associated with metabolic syndrome traits independently of obesity and inflammation.
Lipid metabolism
Metabolic syndrome
Small dense LDL cholesterol
Journal
Nutrition & metabolism
ISSN: 1743-7075
Titre abrégé: Nutr Metab (Lond)
Pays: England
ID NLM: 101231644
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
10
2018
accepted:
10
01
2019
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
27
1
2019
Statut:
epublish
Résumé
Small dense LDL cholesterol (sdLDL-c) has been established to be highly associated with metabolic disorder. However, the relationship between circulating sdLDL-c and the presence of metabolic syndrome (MetS) has not been fully established. A total of 1065 Chinese males (45.07 ± 11.08 years old) without diabetes and general obesity was recruited into a population-based, cross-sectional study. The MetS was defined based on the updated National Cholesterol Education Program/ Adult Treatment Panel III criteria for Asian Americans. Serum sdLDL-c concentration was measured by a homogeneous assay method and its relationship with MetS and its traits was investigated. Serum sdLDL-c concentrations increased gradually with increasing numbers of MetS components ( This study found that high sdLDL-c concentrations were associated with the presence of MetS independently of central obesity and inflammation.
Sections du résumé
BACKGROUND
BACKGROUND
Small dense LDL cholesterol (sdLDL-c) has been established to be highly associated with metabolic disorder. However, the relationship between circulating sdLDL-c and the presence of metabolic syndrome (MetS) has not been fully established.
METHODS
METHODS
A total of 1065 Chinese males (45.07 ± 11.08 years old) without diabetes and general obesity was recruited into a population-based, cross-sectional study. The MetS was defined based on the updated National Cholesterol Education Program/ Adult Treatment Panel III criteria for Asian Americans. Serum sdLDL-c concentration was measured by a homogeneous assay method and its relationship with MetS and its traits was investigated.
RESULTS
RESULTS
Serum sdLDL-c concentrations increased gradually with increasing numbers of MetS components (
CONCLUSIONS
CONCLUSIONS
This study found that high sdLDL-c concentrations were associated with the presence of MetS independently of central obesity and inflammation.
Identifiants
pubmed: 30679939
doi: 10.1186/s12986-019-0334-y
pii: 334
pmc: PMC6341753
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7Déclaration de conflit d'intérêts
The study protocol was approved by the Institutional Review Board of the Sun Yat-sen University, conducted according to the principles expressed in the Declaration of Helsinki and written informed consent was obtained from all participants.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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