Current perspectives of cancer-associated fibroblast in therapeutic resistance: potential mechanism and future strategy.
Cancer-associated fibroblast
Drug resistance
Journal
Cell biology and toxicology
ISSN: 1573-6822
Titre abrégé: Cell Biol Toxicol
Pays: Switzerland
ID NLM: 8506639
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
12
09
2018
accepted:
03
01
2019
revised:
15
12
2018
pubmed:
27
1
2019
medline:
29
8
2020
entrez:
26
1
2019
Statut:
ppublish
Résumé
The goal of cancer eradication has been overshadowed despite the continuous improvement in research and generation of novel cancer therapeutic drugs. One of the undeniable existing problems is drug resistance due to which the paradigm of killing all cancer cells is ineffective. Tumor microenvironment plays a crucial role in inducing drug resistance besides cancer development and progression. Recently, many efforts have been devoted to understand the role of tumor microenvironment in cancer drug resistance as it provides the shelter, nutrition, and paracrine niche for cancer cells. Cancer-associated fibroblasts (CAFs), one major component of tumor microenvironment, reside in symbiotic relationship with cancer cells, supporting them to survive from cancer drugs. The present review summarizes the recent understandings in the role of CAFs in drug resistance in various tumors. Acknowledging the fact that drug resistance depends not only upon cancer cells but also upon the microenvironment niche could guide us to formulate novel cancer drugs and provide the optimal cancer treatment.
Identifiants
pubmed: 30680600
doi: 10.1007/s10565-019-09461-z
pii: 10.1007/s10565-019-09461-z
pmc: PMC6881418
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
407-421Références
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