Optimal dosage of methotrexate for GVHD prophylaxis in umbilical cord blood transplantation.
Endothelial cell damage
Graft-versus-host disease
Methotrexate
Umbilical cord blood transplantation
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
22
08
2018
accepted:
16
01
2019
revised:
28
12
2018
pubmed:
27
1
2019
medline:
18
4
2019
entrez:
26
1
2019
Statut:
ppublish
Résumé
The combination of methotrexate (MTX) and a calcineurin inhibitor is widely used for GVHD prophylaxis in umbilical cord blood transplantation (UCBT). However, the optimal MTX dosage for GVHD prophylaxis in UCBT remains unclear. In the present study, we investigated the impact of MTX dosage on clinical outcomes following UCBT in a single-center retrospective study. Of 70 UCBT recipients included in this study, 37 received MTX at doses of 10 mg/m
Identifiants
pubmed: 30680665
doi: 10.1007/s12185-019-02598-x
pii: 10.1007/s12185-019-02598-x
doi:
Substances chimiques
Tacrolimus
WM0HAQ4WNM
Methotrexate
YL5FZ2Y5U1
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
440-450Références
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