The Tumor Microenvironment in Post-Transplant Lymphoproliferative Disorders.
Epstein-Barr virus
Microenvironment, immunosuppression
Post-transplant lymphoproliferative disorders
Journal
Cancer microenvironment : official journal of the International Cancer Microenvironment Society
ISSN: 1875-2292
Titre abrégé: Cancer Microenviron
Pays: Netherlands
ID NLM: 101322634
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
09
08
2018
accepted:
18
12
2018
pubmed:
27
1
2019
medline:
27
1
2019
entrez:
26
1
2019
Statut:
ppublish
Résumé
Post-transplant lymphoproliferative disorders (PTLDs) cover a broad spectrum of lymphoproliferative lesions arising after solid organ or allogeneic hematopoietic stem cell transplantation. The composition and function of the tumor microenvironment (TME), consisting of all non-malignant constituents of a tumor, is greatly impacted in PTLD through a complex interplay between 4 factors: 1) the graft organ causes immune stimulation through chronic antigen presentation; 2) the therapy to prevent organ rejection interferes with the immune system; 3) the oncogenic Epstein-Barr virus (EBV), present in 80% of PTLDs, has a causative role in the oncogenic transformation of lymphocytes and influences immune responses; 4) interaction with the donor-derived immune cells accompanying the graft. These factors make PTLDs an interesting model to look at cancer-microenvironment interactions and current findings can be of interest for other malignancies including solid tumors. Here we will review the current knowledge of the TME composition in PTLD with a focus on the different factors involved in PTLD development.
Identifiants
pubmed: 30680693
doi: 10.1007/s12307-018-00219-5
pii: 10.1007/s12307-018-00219-5
pmc: PMC6529504
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
3-16Subventions
Organisme : Stichting Tegen Kanker
ID : 2014-083
Organisme : Kom op tegen Kanker
ID : EMH-D5268
Organisme : Universitaire Ziekenhuizen Leuven, KU Leuven
ID : RT0817
Références
Transplantation. 1999 Mar 27;67(6):876-81
pubmed: 10199737
J Biol Chem. 1999 Jun 4;274(23):16085-96
pubmed: 10347160
Am J Pathol. 1999 Jun;154(6):1685-91
pubmed: 10362793
J Virol. 2000 Mar;74(6):2612-9
pubmed: 10684275
Am J Surg Pathol. 2000 May;24(5):733-41
pubmed: 10800993
J Immunol. 2000 Nov 15;165(10):5729-37
pubmed: 11067931
EMBO J. 2000 Dec 15;19(24):6742-50
pubmed: 11118209
Transplantation. 2001 Apr 27;71(8):1076-88
pubmed: 11374406
EMBO J. 2002 Mar 1;21(5):954-65
pubmed: 11867523
J Biol Chem. 2002 Jul 5;277(27):24148-54
pubmed: 11971896
Transplantation. 2002 May 27;73(10):1603-10
pubmed: 12042647
Transplantation. 2002 Aug 27;74(4):501-10
pubmed: 12352909
Virology. 2002 Dec 20;304(2):342-51
pubmed: 12504574
Int J Cancer. 2003 Nov 1;107(2):197-201
pubmed: 12949794
Br J Haematol. 2003 Sep;122(6):927-33
pubmed: 12956763
J Virol. 2004 Feb;78(4):1665-74
pubmed: 14747532
Cancer Res. 2004 Aug 1;64(15):5332-7
pubmed: 15289339
Clin Cancer Res. 2005 Feb 15;11(4):1467-73
pubmed: 15746048
J Allergy Clin Immunol. 2005 Aug;116(2):251-61; quiz 262
pubmed: 16083776
Virus Res. 2006 Aug;119(2):134-45
pubmed: 16545476
Cancer Res. 2006 Jun 1;66(11):5716-22
pubmed: 16740709
Blood. 2006 Oct 1;108(7):2280-9
pubmed: 16757686
J Exp Med. 2006 Oct 2;203(10):2281-92
pubmed: 16954372
Blood. 2007 Feb 1;109(3):1138-46
pubmed: 16985171
J Virol. 2007 Jan;81(2):474-82
pubmed: 17079298
Blood. 2007 Mar 15;109(6):2571-8
pubmed: 17119113
BMC Cancer. 2006 Dec 08;6:283
pubmed: 17156439
Blood. 2007 Aug 15;110(4):1326-9
pubmed: 17438085
Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13134-9
pubmed: 17670934
Blood. 2008 Jan 1;111(1):292-301
pubmed: 17720884
Int J Cancer. 2008 Feb 15;122(4):769-76
pubmed: 17935139
J Immunol. 2007 Dec 15;179(12):8225-34
pubmed: 18056366
Blood. 2008 Mar 15;111(6):3220-4
pubmed: 18203952
Hematol Oncol. 2008 Dec;26(4):199-211
pubmed: 18457340
PLoS Med. 2008 May 6;5(5):e100
pubmed: 18462013
Am J Pathol. 2008 Jul;173(1):195-204
pubmed: 18502823
J Pathol. 2008 Sep;216(1):83-92
pubmed: 18566961
J Virol. 2008 Oct;82(20):10175-87
pubmed: 18684838
J Exp Med. 2008 Nov 24;205(12):2763-79
pubmed: 19001139
Blood. 2009 Mar 19;113(12):2765-3775
pubmed: 19096012
J Immunol. 2009 Feb 15;182(4):1799-809
pubmed: 19201831
Transpl Immunol. 2009 May;21(1):43-9
pubmed: 19233271
Curr Opin HIV AIDS. 2008 May;3(3):362-7
pubmed: 19372991
J Exp Med. 2009 Sep 28;206(10):2091-9
pubmed: 19720839
Leuk Lymphoma. 2009 Dec;50(12):2005-12
pubmed: 19860626
Cancer Sci. 2010 Jan;101(1):29-35
pubmed: 19886912
N Engl J Med. 2010 Mar 11;362(10):875-85
pubmed: 20220182
Int J Cancer. 2011 May 15;128(10):2501-8
pubmed: 20715107
Haematologica. 2011 Feb;96(2):269-76
pubmed: 21071500
Am J Transplant. 2011 Feb;11(2):336-47
pubmed: 21219573
Blood. 2011 Apr 21;117(16):4315-22
pubmed: 21300977
J Clin Oncol. 2011 May 10;29(14):1864-75
pubmed: 21482977
J Exp Med. 2011 May 9;208(5):987-99
pubmed: 21536743
Histopathology. 2011 Jul;59(1):152-6
pubmed: 21771035
Int J Cancer. 2012 Sep 1;131(5):1142-52
pubmed: 22025264
Lung Cancer. 2012 Apr;76(1):118-22
pubmed: 22088939
Clin Cancer Res. 2012 Mar 15;18(6):1611-8
pubmed: 22271878
Transpl Immunol. 2012 Aug;27(1):48-51
pubmed: 22342937
Transpl Int. 2012 May;25(5):545-54
pubmed: 22353435
PLoS Pathog. 2012;8(5):e1002704
pubmed: 22615564
Clin Cancer Res. 2012 Jul 15;18(14):3762-71
pubmed: 22645050
Med Oncol. 2012 Dec;29(5):3614-9
pubmed: 22791223
Am J Clin Pathol. 2012 Oct;138(4):568-78
pubmed: 23010712
Leuk Lymphoma. 2013 Oct;54(10):2190-9
pubmed: 23402267
Leuk Lymphoma. 2013 Nov;54(11):2433-40
pubmed: 23442063
Clin Cancer Res. 2013 Apr 15;19(8):2036-47
pubmed: 23444223
Am J Transplant. 2013 May;13(5):1305-16
pubmed: 23489474
Clin Cancer Res. 2013 Jul 1;19(13):3462-73
pubmed: 23674495
Clin Dev Immunol. 2013;2013:150835
pubmed: 23690819
J Immunol. 2013 Nov 15;191(10):4989-95
pubmed: 24108698
Pediatr Transplant. 2013 Dec;17(8):806-14
pubmed: 24118875
J Virol. 2014 Jun;88(12):6660-71
pubmed: 24696473
Nat Rev Cancer. 2014 Aug;14(8):517-34
pubmed: 25008267
Br J Haematol. 2014 Sep;166(6):875-90
pubmed: 25041527
PLoS One. 2014 Jul 24;9(7):e102977
pubmed: 25057852
Cancers (Basel). 2014 Aug 06;6(3):1615-30
pubmed: 25101570
Haematologica. 2015 Jul;100(7):e275-9
pubmed: 25795716
Semin Cancer Biol. 2015 Oct;34:58-69
pubmed: 25953434
Biomark Med. 2015;9(5):473-82
pubmed: 25985176
Blood. 2015 Aug 13;126(7):863-72
pubmed: 25999451
Semin Cancer Biol. 2015 Oct;34:52-7
pubmed: 26118690
Nat Rev Cancer. 2015 Aug;15(8):457-72
pubmed: 26205340
Nat Rev Immunol. 2015 Aug;15(8):486-99
pubmed: 26205583
Blood. 2015 Nov 12;126(20):2274-83
pubmed: 26384356
Curr Top Microbiol Immunol. 2015;390(Pt 1):287-313
pubmed: 26424651
Am J Transplant. 2016 Feb;16(2):414-25
pubmed: 26780579
N Engl J Med. 2016 Mar 3;374(9):896-8
pubmed: 26962927
Hematol Oncol. 2017 Sep;35(3):296-302
pubmed: 27060262
Blood Cancer J. 2016 May 06;6:e417
pubmed: 27152844
J Exp Med. 2016 Sep 19;213(10):2065-80
pubmed: 27621419
World J Transplant. 2016 Sep 24;6(3):505-16
pubmed: 27683629
Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6467-E6475
pubmed: 27698133
Mod Pathol. 2017 Mar;30(3):370-381
pubmed: 28059091
N Engl J Med. 2017 Jan 12;376(2):191-192
pubmed: 28076715
Immunol Rev. 2017 Mar;276(1):80-96
pubmed: 28258692
Transplantation. 2017 Sep;101(9):2009-2016
pubmed: 28376031
PLoS Pathog. 2017 Jul 21;13(7):e1006503
pubmed: 28732079
F1000Res. 2017 Jul 26;6:null
pubmed: 28781750
Sci Rep. 2017 Sep 7;7(1):10813
pubmed: 28883511
Neuropathology. 2018 Apr;38(2):125-134
pubmed: 29067721
Indian J Hematol Blood Transfus. 2017 Dec;33(4):492-499
pubmed: 29075059
Cell Immunol. 2017 Dec;322:1-14
pubmed: 29079339
Exp Gerontol. 2018 May;105:4-9
pubmed: 29111233
Front Immunol. 2017 Nov 24;8:1658
pubmed: 29225606
N Engl J Med. 2018 Feb 8;378(6):549-562
pubmed: 29414277
Cancer Treat Rev. 2018 Apr;65:22-32
pubmed: 29502037
Front Oncol. 2018 Mar 07;8:54
pubmed: 29564225
Transplant Proc. 2018 Mar;50(2):444-448
pubmed: 29579824
Infect Agent Cancer. 2018 Apr 10;13:14
pubmed: 29643934
Pathogens. 2018 Apr 13;7(2):
pubmed: 29652813
Sci Immunol. 2018 Jun 1;3(24):
pubmed: 29858286
Leuk Lymphoma. 2019 Feb;60(2):376-384
pubmed: 30033844
J Leukoc Biol. 2018 Oct;104(4):821-832
pubmed: 30040158
Lancet. 1995 Jan 7;345(8941):9-13
pubmed: 7799740
Hum Gene Ther. 1994 Mar;5(3):381-97
pubmed: 8018749
Hum Pathol. 1996 Feb;27(2):157-64
pubmed: 8617457
Cancer. 1998 May 15;82(10):1978-87
pubmed: 9587133
J Pathol. 1998 Feb;184(2):177-84
pubmed: 9602709