The Role of Dorsal Premotor Cortex in Resolving Abstract Motor Rules: Converging Evidence From Transcranial Magnetic Stimulation and Cognitive Modeling.

In this study, repetitive transcranial magnetic stimulation (rTMS) was applied over left dorsal premotor cortex (PMd) while participants performed a novel task paradigm that required planning of responses in accordance with both instructed rules and present stimuli. rTMS is a noninvasive form of neurostimulation that can interfere with ongoing processing of a targeted cortical region, resulting in a transient "virtual lesion" that can reveal the contribution of the region to ongoing behavior. Increased response times (RTs) were observed specifically when rTMS was applied over PMd while participants were preparing to execute a complex response to an uninstructed stimulus. To further delineate the effect of stimulation, condition-specific RT distributions were modeled as three-parameter Weibull distributions through hierarchical Bayesian modeling (HBM). Comparison of the estimated parameters to those of a paired control demonstrated that while PMd-rTMS slightly decreased nondecision time, it also greatly increased the variability in the RT distribution. This increased variability resulted in an overall increase in predicted mean RT and is consistent with a delay in cognitive processes. In conjunction, an ACT-R cognitive model of the task was developed in order to systematically test alternative hypotheses on the potential cognitive functions that may be affected by stimulation of PMd. ACT-R simulations suggested that participant's behavior was due to an effect of TMS on a "re-planning" process, indicating that PMd may be specifically involved in planning of complex motor responses to specific visual stimuli. In conjunction with the HBM modeling effort, these results suggest that PMd-rTMS is capable of pausing or slowing the execution of a motor response-planning process.

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