LC-MS guided isolation and dereplication of Lycopodium alkaloids from Lycopodium cernuum var. sikkimense of different geographical origins.

Alkaloids / chemistry Chromatography, Liquid Geography Lycopodium / chemistry Models, Molecular Molecular Conformation Tandem Mass Spectrometry
Cernuine (PubChem CID: 442472) Chemical compounds studied in this article Dereplication Isolation LC-MS analysis Lycocernuine (PubChem CID: 442481) Lycocernuskines Lycopodiaceae Lycopodium cernuum var. sikkimense

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Apr 2019
Historique:
received: 27 08 2018
revised: 28 12 2018
accepted: 10 01 2019
pubmed: 27 1 2019
medline: 19 3 2019
entrez: 26 1 2019
Statut: ppublish

Résumé

Lycopodium alkaloids (LAs) are the characteristic metabolites of club mosses. Chemical differences often exist in different specimens of a single plant species collected from different geographic origins. In this study, a preliminary LC-MS detection and dereplication analyses of alkaloidal constituents of Lycopodium cernuum var. sikkimense (Müll. Hal.) C.B. Clarke (LCVS2) collected from Fujian province led to the isolation and characterization of three undescribed LAs, lycocernuskines A-C, and six known cernuane-type LAs. The known compounds were previously isolated from the same plant species (LCVS1) collected from Chongqing, and so their dereplication in LCVS2 was accomplished based on their retention times (t

Identifiants

DOI: 10.1016/j.phytochem.2019.01.006 PMID: 30682681
pubmed: 30682681
pii: S0031-9422(18)30500-4
doi: 10.1016/j.phytochem.2019.01.006
pii:
doi:

Substances chimiques

Alkaloids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

25-30

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Yu Tang (Y)

Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, PR China.

Na Li (N)

Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Taizhou, 318000, Zhejiang, PR China.

Yike Zou (Y)

Department of Chemistry, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Yanran Ai (Y)

Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.

Guang-Lei Ma (GL)

Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, PR China.

Ezzat E A Osman (EEA)

Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, PR China; Laboratory of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornaish El-Nile St., Giza, 12411, Egypt.

Juan Xiong (J)

Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, PR China.

Junmin Li (J)

Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Taizhou, 318000, Zhejiang, PR China. Electronic address: lijm@tzc.edu.cn.

Ze-Xin Jin (ZX)

Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Taizhou, 318000, Zhejiang, PR China.

Jin-Feng Hu (JF)

Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, PR China; Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Taizhou, 318000, Zhejiang, PR China. Electronic address: jfhu@fudan.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › LC-MS guided isolation and dereplication of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › LC-MS guided isolation and dereplication of...
questionsmedicales.fr › Disciplines des sciences naturelles › Sciences de la Terre › Géographie › LC-MS guided isolation and dereplication of...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Lycopodiaceae › Lycopodium › LC-MS guided isolation and dereplication of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › LC-MS guided isolation and dereplication of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › LC-MS guided isolation and dereplication of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › LC-MS guided isolation and dereplication of...