Breast Cancer Systemic Treatments and Upper Limb Lymphedema: A Risk-Assessment Platform Encompassing Tumor-Specific Pathological Features Reveals the Potential Role of Trastuzumab.

anti-HER2 axillary lymph nodes dissection breast cancer breast cancer related lymphedema chemotherapy extranodal extension lymphovascular invasion radiation therapy taxanes therapy trastuzumab

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
24 Jan 2019
Historique:
received: 05 12 2018
revised: 22 01 2019
accepted: 22 01 2019
entrez: 27 1 2019
pubmed: 27 1 2019
medline: 27 1 2019
Statut: epublish

Résumé

Breast cancer related lymphedema (BCRL) is frequent but strategies for an individualized risk assessment are lacking. We aimed to define whether tumor-specific pathological features, coupled with clinical and therapeutic data, could help identify patients at risk. Data from 368 patients with node-positive breast cancers were retrospectively collected, including 75 patients with BCRL (0.4⁻25.6 years follow-up). BCRL was assessed during the standard follow-up oncology visits using the circumferential measurement. Clinicopathologic and therapeutic factors associated with BCRL were integrated into a Cox proportional hazards regression model. Lymphovascular invasion (LVI) was more common in BCRL patients (

Identifiants

pubmed: 30682851
pii: jcm8020138
doi: 10.3390/jcm8020138
pmc: PMC6406664
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Marco Invernizzi (M)

Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", Viale Piazza D'Armi 1, 28100 Novara, Italy. marco.invernizzi@med.uniupo.it.

Anna Michelotti (A)

Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy. anna.michelotti@studenti.unimi.it.
Division of Medical Oncology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy. anna.michelotti@studenti.unimi.it.

Marianna Noale (M)

National Research Council (CNR), Neuroscience Institute Aging Branch, Via Giustiniani 2, 35128 Padua, Italy. marianna.noale@in.cnr.it.

Gianluca Lopez (G)

Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy. gianluca.lopez@unimi.it.
School of Pathology, University of Milan, Via Festa del Perdono 7, 20122 Milano, Italy. gianluca.lopez@unimi.it.

Letterio Runza (L)

Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy. letterio.runza@policlinico.mi.it.

Massimo Giroda (M)

Division of Breast Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy. massimo.giroda@policlinico.mi.it.

Luca Despini (L)

Division of Breast Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy. luca.despini@policlinico.mi.it.

Concetta Blundo (C)

Division of Breast Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy. concetta.blundo@policlinico.mi.it.

Stefania Maggi (S)

National Research Council (CNR), Neuroscience Institute Aging Branch, Via Giustiniani 2, 35128 Padua, Italy. stefania.maggi@in.cnr.it.

Donatella Gambini (D)

Division of Medical Oncology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy. donatella.gambini@policlinico.mi.it.

Nicola Fusco (N)

Division of Pathology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy. nicola.fusco@unimi.it.
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Della Commenda 10, 20122 Milan, Italy. nicola.fusco@unimi.it.

Classifications MeSH