Benchtop low-field

Antimalarials / analysis Counterfeit Drugs / analysis Proton Magnetic Resonance Spectroscopy / methods Urological Agents / analysis
Antimalarial medicines Benchtop NMR Erectile dysfunction medicines Falsified medicines Low-field NMR Quantitative NMR

Journal

Talanta
ISSN: 1873-3573
Titre abrégé: Talanta
Pays: Netherlands
ID NLM: 2984816R

Informations de publication

Date de publication:
01 May 2019
Historique:
received: 13 10 2018
revised: 01 12 2018
accepted: 03 12 2018
entrez: 27 1 2019
pubmed: 27 1 2019
medline: 23 2 2019
Statut: ppublish

Résumé

Falsified medicines represent a serious threat to public health. Among the different measures to effectively combat this scourge, analytical methods play a key role in their detection and removal from the market before they reach patients. The present study evaluates for the first time the potential of a benchtop low-field (LF) Nuclear Magnetic Resonance (NMR) spectrometer for uncovering drug falsification by focusing on the analysis of fifteen erectile dysfunction and nine antimalarial medicines, the most commonly reported falsified medicines in developed and developing countries respectively. After a simple and rapid sample preparation and ≈ 5 min of spectrum recording, LF

Identifiants

DOI: 10.1016/j.talanta.2018.12.005 PMID: 30683346
pubmed: 30683346
pii: S0039-9140(18)31272-4
doi: 10.1016/j.talanta.2018.12.005
pii:
doi:

Substances chimiques

Antimalarials 0
Counterfeit Drugs 0
Urological Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

163-173

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Gaëtan Assemat (G)

Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, Université de Toulouse, 118 route de Narbonne, 31062 Toulouse cedex, France.

Stéphane Balayssac (S)

Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, Université de Toulouse, 118 route de Narbonne, 31062 Toulouse cedex, France.

Anna Gerdova (A)

Oxford Instruments Industrial Analysis, Tubney Woods, Abingdon, Oxfordshire OX13 5QX, United Kingdom.

Véronique Gilard (V)

Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, Université de Toulouse, 118 route de Narbonne, 31062 Toulouse cedex, France.

Céline Caillet (C)

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Vientiane, Lao PDR and Infectious Diseases Data Observatory, Centre for Tropical Medicine & Global Health, University of Oxford, UK.

David Williamson (D)

Oxford Instruments Industrial Analysis, Tubney Woods, Abingdon, Oxfordshire OX13 5QX, United Kingdom.

Myriam Malet-Martino (M)

Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, Université de Toulouse, 118 route de Narbonne, 31062 Toulouse cedex, France. Electronic address: martino@chimie.ups-tlse.fr.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Benchtop low-field
questionsmedicales.fr › Préparations pharmaceutiques › Médicaments non conformes aux normes › Médicaments contrefaits › Benchtop low-field
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Spectroscopie par résonance magnétique du proton › Benchtop low-field
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Médicaments génito-urinaires › Agents urologiques › Benchtop low-field