Functions of Microtubule Disassembly during Neurite Pruning.
axon
dendrite
microtubule
plus end
pruning
tau
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
19
10
2018
revised:
27
12
2018
accepted:
02
01
2019
pubmed:
27
1
2019
medline:
25
2
2020
entrez:
27
1
2019
Statut:
ppublish
Résumé
Large-scale neurite pruning, the developmentally regulated degeneration of axons or dendrites, is an important specificity mechanism during neuronal circuit formation. Pruning is usually restricted to single neurite branches and can occur by local degeneration or retraction. How this spatial regulation is achieved, and what triggers degeneration locally, are still poorly understood. At the cellular level, pruning involves local cytoskeleton disassembly before branch removal. Recent evidence suggests that microtubule disassembly is the local trigger and that the specific local microtubule organization of axons or dendrites determines where and how neurites degenerate. Based on these data, we propose a general model for spatial pruning regulation by microtubules and discuss how microtubule-associated proteins such as Tau could contribute to these regulatory aspects.
Identifiants
pubmed: 30683460
pii: S0962-8924(19)30002-9
doi: 10.1016/j.tcb.2019.01.002
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
291-297Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.