Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
16
01
2018
accepted:
21
12
2018
pubmed:
27
1
2019
medline:
13
11
2019
entrez:
27
1
2019
Statut:
ppublish
Résumé
Herpes simplex encephalitis (HSE), caused by HSV type 1 (HSV-1) infection, is an acute neuroinflammatory condition of the CNS and remains the most common type of sporadic viral encephalitis worldwide. Studies in humans have shown that susceptibility to HSE depends in part on the genetic make-up of the host, with deleterious mutations in the TLR3/type I IFN axis underlying some cases of childhood HSE. Using an in vivo chemical mutagenesis screen for HSV-1 susceptibility in mice, we identified a susceptible pedigree carrying a causal truncating mutation in the
Identifiants
pubmed: 30683700
pii: jimmunol.1800063
doi: 10.4049/jimmunol.1800063
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1479-1493Subventions
Organisme : CIHR
ID : CTP-87520
Pays : Canada
Organisme : CIHR
ID : MOP-238757
Pays : Canada
Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.