Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis.
dopamine
dyshomeostasis
inflammation
interoception
lesion
metacognition
network
Journal
Journal of neurology, neurosurgery, and psychiatry
ISSN: 1468-330X
Titre abrégé: J Neurol Neurosurg Psychiatry
Pays: England
ID NLM: 2985191R
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
21
11
2018
revised:
03
01
2019
accepted:
04
01
2019
pubmed:
27
1
2019
medline:
14
3
2020
entrez:
27
1
2019
Statut:
ppublish
Résumé
Fatigue is one of the most common symptoms in multiple sclerosis (MS), with a major impact on patients' quality of life. Currently, treatment proceeds by trial and error with limited success, probably due to the presence of multiple different underlying mechanisms. Recent neuroscientific advances offer the potential to develop tools for differentiating these mechanisms in individual patients and ultimately provide a principled basis for treatment selection. However, development of these tools for differential diagnosis will require guidance by pathophysiological and cognitive theories that propose mechanisms which can be assessed in individual patients. This article provides an overview of contemporary pathophysiological theories of fatigue in MS and discusses how the mechanisms they propose may become measurable with emerging technologies and thus lay a foundation for future personalised treatments.
Identifiants
pubmed: 30683707
pii: jnnp-2018-320050
doi: 10.1136/jnnp-2018-320050
pmc: PMC6581095
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
642-651Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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