Micromanaging human placental function: differential microRNA expression in feto-placental endothelial cells of gestational diabetes pregnancies.

Diabetes, Gestational Endothelial Cells Female Humans MicroRNAs Placenta Pregnancy
endothelial cell gestational diabetes miRNA placenta

Journal

Clinical science (London, England : 1979)
ISSN: 1470-8736
Titre abrégé: Clin Sci (Lond)
Pays: England
ID NLM: 7905731

Informations de publication

Date de publication:
31 01 2019
Historique:
received: 21 11 2018
revised: 08 01 2019
accepted: 14 01 2019
entrez: 27 1 2019
pubmed: 27 1 2019
medline: 29 10 2019
Statut: epublish

Résumé

Healthy development in utero relies on the appropriate exchange of nutrients and other signalling between the maternal and fetal circulations. Disruption to this fine balance is associated with several pregnancy and adverse birth outcomes, including gestational diabetes mellitus (GDM). This is a complex condition influenced by genetic, environment and potentially epigenetic factors in association with a range of altered developmental outcomes. A recent study, published in Clinical Science, explores miRNAs as a molecular mechanism underpinning the altered function of placental endothelial cells in GDM pregnancies.

Identifiants

DOI: 10.1042/CS20180901 PMID: 30683714
pubmed: 30683714
pii: CS20180901
doi: 10.1042/CS20180901
doi:

Substances chimiques

MicroRNAs 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

315-319

Commentaires et corrections

Type : CommentOn

Informations de copyright

© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Auteurs

Boris Novakovic (B)

Epigenetics Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, VIC, 3052, Australia and Department of Paediatrics, University of Melbourne, Parkville, VIC, 3052, Australia.

Toby Mansell (T)

Epigenetics Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, VIC, 3052, Australia and Department of Paediatrics, University of Melbourne, Parkville, VIC, 3052, Australia.

Richard Saffery (R)

Epigenetics Research, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, VIC, 3052, Australia and Department of Paediatrics, University of Melbourne, Parkville, VIC, 3052, Australia Richard.saffery@mcri.edu.au.
ORCID: 0000-0002-9510-4181

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Classifications MeSH

questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète gestationnel › Micromanaging human placental function:...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Micromanaging human placental function:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Micromanaging human placental function:...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Micromanaging human placental function:...
questionsmedicales.fr › Structures de l'embryon › Placenta › Micromanaging human placental function:...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Micromanaging human placental function:...