Altered pharmacokinetics of combined oral contraceptives in obesity - multistudy assessment.
Clearance
Combined oral contraceptives
Obesity
Pharmacokinetics
Volume of distribution
Journal
Contraception
ISSN: 1879-0518
Titre abrégé: Contraception
Pays: United States
ID NLM: 0234361
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
06
08
2018
revised:
19
12
2018
accepted:
19
12
2018
pubmed:
27
1
2019
medline:
19
5
2020
entrez:
27
1
2019
Statut:
ppublish
Résumé
The objective was to evaluate the pharmacokinetics (PKs) of levonorgestrel (LNG)-containing combined oral contraceptives (COCs) in obese women. We pooled and reanalyzed data from 89 women with different body mass index (BMI) categories from four clinical studies. The LNG and ethinyl estradiol (EE) PKs were analyzed utilizing a zero-order absorption (K Increasing of body habitus metrics is correlated with decreasing C The primary effects of obesity on LNG and EE were a modest increase in CL and a marked increase in distribution parameters. We observed no obesity-related differences in trough LNG and EE concentrations. This population PK analysis demonstrated reduced systemic exposure to LNG/EE oral contraceptives in obese subjects (C
Identifiants
pubmed: 30684471
pii: S0010-7824(19)30013-7
doi: 10.1016/j.contraception.2018.12.009
pmc: PMC6441376
mid: NIHMS1519340
pii:
doi:
Substances chimiques
Contraceptives, Oral, Combined
0
Ethinyl Estradiol
423D2T571U
Levonorgestrel
5W7SIA7YZW
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
256-263Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM024211
Pays : United States
Organisme : NIGMS NIH HHS
ID : R37 GM024211
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002369
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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