Characterisation and the effects of bilirubin binding to human fibrinogen.

Bilirubin / chemistry Blood Coagulation Blood Coagulation Tests Circular Dichroism Fibrinogen / chemistry Fluorometry Humans Oxidation-Reduction Protein Binding Thermodynamics
Binding Circular dichroism Coagulation Fluorimetry Protein oxidation

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 May 2019
Historique:
received: 30 10 2018
revised: 11 01 2019
accepted: 22 01 2019
pubmed: 27 1 2019
medline: 25 6 2019
entrez: 27 1 2019
Statut: ppublish

Résumé

Fibrinogen, a protein involved in blood coagulation, is very susceptible to oxidation. Oxidation alters its function and usually makes it more thrombogenic. Bilirubin, an end-product of the haem degradation in vertebrates, is known for its antioxidant properties. The present paper describes interaction between fibrinogen and bilirubin, and the influence of bilirubin on the formation of fibrin and protection against oxidation. The binding constant of 4.5 × 10

Identifiants

DOI: 10.1016/j.ijbiomac.2019.01.124 PMID: 30684573
pubmed: 30684573
pii: S0141-8130(18)35880-X
doi: 10.1016/j.ijbiomac.2019.01.124
pii:
doi:

Substances chimiques

Fibrinogen 9001-32-5
Bilirubin RFM9X3LJ49

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

74-79

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Nikola Gligorijević (N)

Institute for the Application of Nuclear Energy, Department for Metabolism, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia. Electronic address: nikolag@inep.co.rs.

Simeon Minić (S)

Faculty of Chemistry, Department of Biochemistry, Centre of Excellence for Molecular Food Sciences, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.

Dragana Robajac (D)

Institute for the Application of Nuclear Energy, Department for Metabolism, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.

Milan Nikolić (M)

Faculty of Chemistry, Department of Biochemistry, Centre of Excellence for Molecular Food Sciences, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.

Tanja Ćirković Veličković (T)

Faculty of Chemistry, Department of Biochemistry, Centre of Excellence for Molecular Food Sciences, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia; Ghent University Global Campus, Yeonsu-gu, Incheon, South Korea; Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium; Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia.

Olgica Nedić (O)

Institute for the Application of Nuclear Energy, Department for Metabolism, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Pigments biliaires › Bilirubine › Characterisation and the effects of bilirubin...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Coagulation sanguine › Characterisation and the effects of bilirubin...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Tests hématologiques › Tests de coagulation sanguine › Characterisation and the effects of bilirubin...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Dichroïsme circulaire › Characterisation and the effects of bilirubin...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Fibrinogène › Characterisation and the effects of bilirubin...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Photométrie › Mesures de luminescence › Fluorimétrie › Characterisation and the effects of bilirubin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Characterisation and the effects of bilirubin...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Characterisation and the effects of bilirubin...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Characterisation and the effects of bilirubin...
questionsmedicales.fr › Phénomènes physiques › Thermodynamique › Characterisation and the effects of bilirubin...