Ru(II)/N-N/PPh

Animals Antineoplastic Agents / chemical synthesis Cattle Cell Line, Tumor Coordination Complexes / chemical synthesis DNA / chemistry Humans Ligands Phosphines / chemical synthesis Protein Binding Serum Albumin, Human / metabolism Viscosity

Journal

Journal of inorganic biochemistry
ISSN: 1873-3344
Titre abrégé: J Inorg Biochem
Pays: United States
ID NLM: 7905788

Informations de publication

Date de publication:
04 2019
Historique:
received: 09 08 2018
revised: 10 01 2019
accepted: 12 01 2019
pubmed: 27 1 2019
medline: 6 5 2020
entrez: 27 1 2019
Statut: ppublish

Résumé

The rational design of anticancer agents that acts in specific biological targets is one of the most effective strategies for developing chemotherapeutic agents. Aiming at obtaining new ruthenium (II) compounds with good cytotoxicity against tumor cells, a series of new complexes of general formula [RuCl(PPh

Identifiants

DOI: 10.1016/j.jinorgbio.2019.01.006 PMID: 30684760
pubmed: 30684760
pii: S0162-0134(18)30473-2
doi: 10.1016/j.jinorgbio.2019.01.006
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Coordination Complexes 0
Ligands 0
Phosphines 0
DNA 9007-49-2
calf thymus DNA 91080-16-9
Serum Albumin, Human ZIF514RVZR

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

70-83

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Gabriel H Ribeiro (GH)

Universidade Federal de São Carlos, Departamento de Química, São Carlos, SP, Brazil. Electronic address: gabrielhenri10@hotmail.com.

Legna Colina-Vegas (L)

Universidade Federal de São Carlos, Departamento de Química, São Carlos, SP, Brazil.

Juan C T Clavijo (JCT)

Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, SP, Brazil.

Javier Ellena (J)

Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, SP, Brazil.

Marcia R Cominetti (MR)

Universidade Federal de São Carlos, Departamento de Gerontologia, São Carlos, SP, Brazil.

Alzir A Batista (AA)

Universidade Federal de São Carlos, Departamento de Química, São Carlos, SP, Brazil. Electronic address: daab@ufscar.br.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ru(II)/N-N/PPh
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Ru(II)/N-N/PPh
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Ru(II)/N-N/PPh
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Ru(II)/N-N/PPh
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Ru(II)/N-N/PPh
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Ru(II)/N-N/PPh
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ru(II)/N-N/PPh
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Ru(II)/N-N/PPh
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphines › Ru(II)/N-N/PPh
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Ru(II)/N-N/PPh
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Sérumalbumine › Sérum-albumine humaine › Ru(II)/N-N/PPh
questionsmedicales.fr › Phénomènes chimiques › Viscosité › Ru(II)/N-N/PPh