Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan.
Aged
Aged, 80 and over
Cadmium
/ adverse effects
Cadmium Poisoning
/ blood
Creatinine
/ urine
Environmental Exposure
/ adverse effects
Environmental Monitoring
Environmental Pollutants
/ adverse effects
Female
Hospitals
Humans
Japan
Kidney Diseases
/ chemically induced
Male
Middle Aged
Sex Distribution
Cadmium
Hospital
Nephropathy
Screening
ß2-microglobulin
Journal
Environmental health and preventive medicine
ISSN: 1347-4715
Titre abrégé: Environ Health Prev Med
Pays: Japan
ID NLM: 9609642
Informations de publication
Date de publication:
26 Jan 2019
26 Jan 2019
Historique:
received:
24
10
2018
accepted:
16
01
2019
entrez:
28
1
2019
pubmed:
28
1
2019
medline:
1
5
2019
Statut:
epublish
Résumé
In health examinations for local inhabitants in cadmium-polluted areas, only healthy people are investigated, suggesting that patients with severe cadmium nephropathy or itai-itai disease may be overlooked. Therefore, we performed hospital-based screening to detect patients with cadmium nephropathy in two core medical institutes in cadmium-polluted areas in Akita prefecture, Japan. Subjects for this screening were selected from patients aged 60 years or older with elevated serum creatinine levels and no definite renal diseases. We enrolled 35 subjects from a hospital in Odate city and 22 from a clinic in Kosaka town. Urinary ß The criteria for renal tubular dysfunction and the over-accumulation of cadmium were set as a urinary ß This hospital-based screening is a very effective strategy for detecting patients with cadmium nephropathy in cadmium-polluted areas, playing a complementary role in health examinations for local inhabitants. No. 6, date of registration: 6 June, 2010 (Akita Rosai Hospital), and No. 1117, date of registration: 26 December, 2013 (Akita University).
Sections du résumé
BACKGROUND
BACKGROUND
In health examinations for local inhabitants in cadmium-polluted areas, only healthy people are investigated, suggesting that patients with severe cadmium nephropathy or itai-itai disease may be overlooked. Therefore, we performed hospital-based screening to detect patients with cadmium nephropathy in two core medical institutes in cadmium-polluted areas in Akita prefecture, Japan.
METHODS
METHODS
Subjects for this screening were selected from patients aged 60 years or older with elevated serum creatinine levels and no definite renal diseases. We enrolled 35 subjects from a hospital in Odate city and 22 from a clinic in Kosaka town. Urinary ß
RESULTS
RESULTS
The criteria for renal tubular dysfunction and the over-accumulation of cadmium were set as a urinary ß
CONCLUSIONS
CONCLUSIONS
This hospital-based screening is a very effective strategy for detecting patients with cadmium nephropathy in cadmium-polluted areas, playing a complementary role in health examinations for local inhabitants.
REGISTRATION NUMBER
BACKGROUND
No. 6, date of registration: 6 June, 2010 (Akita Rosai Hospital), and No. 1117, date of registration: 26 December, 2013 (Akita University).
Identifiants
pubmed: 30684957
doi: 10.1186/s12199-019-0762-3
pii: 10.1186/s12199-019-0762-3
pmc: PMC6347770
doi:
Substances chimiques
Environmental Pollutants
0
Cadmium
00BH33GNGH
Creatinine
AYI8EX34EU
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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