The Alstoscholarisine Alkaloids: Isolation, Structure Determination, Biogenesis, Biological Evaluation, and Synthesis.
Biogenesis
Enantioselective synthesis
Indole alkaloids
Isolation
Stem cell proliferation
Total synthesis
Journal
The Alkaloids. Chemistry and biology
ISSN: 1099-4831
Titre abrégé: Alkaloids Chem Biol
Pays: United States
ID NLM: 9812842
Informations de publication
Date de publication:
Historique:
entrez:
28
1
2019
pubmed:
28
1
2019
medline:
18
4
2019
Statut:
ppublish
Résumé
The alstoscholarisines are a small family of biologically and structurally interesting polycyclic monoterpenoid indole alkaloids isolated from the leaf extracts of Alstonia scholaris. The alkaloids can be divided into three different subtypes based upon their structures and putative biogenesis: (1) (-)-alstoscholarisines A-E, (2) (+)-alstoscholarisine G, and (3) (+)-alstoscholarisines H-J. This review discusses the isolation, structure determination, biological activity, and proposed biosynthesis of these metabolites. In addition, synthetic studies on the alkaloids are described including total syntheses of racemic alstoscholarisines A-E, a total synthesis of (-)-alstoscholarisine A, and a synthesis of racemic alstoscholarisine H.
Identifiants
pubmed: 30685049
pii: S1099-4831(18)30028-2
doi: 10.1016/bs.alkal.2018.09.001
pii:
doi:
Substances chimiques
Secologanin Tryptamine Alkaloids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
115-150Informations de copyright
© 2019 Elsevier Inc. All rights reserved.